, 2022 Additional file 1: Supplementary Figs. S1-S5. and primer sequences used in qPCR experiments. Figure S1. RNAseq analysis and HAoEC flow marker validation. Figure S2. Validation of used flow set up by comparison with existing data. Fig. S3.
Jerome Jatzlau (8115377) +9 more
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Serum proteome profiling identifies novel and powerful markers of cystic fibrosis liver disease. [PDF]
, 2013 Cystic Fibrosis associated liver disease (CFLD) develops in approximately 30% of CF patients. However, routine sensitive diagnostic tools for CFLD are lacking. Within this study, we aimed to identify new experimental biomarkers for the detection of CFLD.
Richard Schulz +26 more
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Endoglin-Targeted Cancer Therapy [PDF]
Current Drug Delivery, 2011 Vascular-targeting antiangiogenic therapy (VTAT) of cancer can be advantageous over conventional tumor cell targeted cancer therapy if an appropriate target is found. Our hypothesis is that endoglin (ENG; CD105) is an excellent target in VTAT. ENG is selectively expressed on vascular and lymphatic endothelium in tumors.
Ben K, Seon +11 more
openaire +2 more sources
Frontiers in Genetics, 2015 Mutations in the endoglin gene (ENG) are responsible for approximately 50% of all cases with Hereditary Hemorrhagic Telangectasia (HHT). Because of the absence of effective treatments for HHT symptoms, studies aimed at identifying novel biological ...
Elisa eRossi +2 more
doaj +1 more source
Multiple delivery of siRNA against endoglin into murine mammary adenocarcinoma prevents angiogenesis and delays tumor growth. [PDF]
PLoS ONE, 2013 Endoglin is a transforming growth factor-β (TGF- β) co-receptor that participates in the activation of a signaling pathway that mediates endothelial cell proliferation and migration in angiogenic tumor vasculature.
Tanja Dolinsek +8 more
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Developmentally Inspired, Mechanical-Metabolic Dual Gradient Osteochondral Constructs Bridging Regeneration and Therapeutic Screening. [PDF]
Adv Sci (Weinh)A developmentally inspired osteochondral construct integrates mechanical and metabolic dual gradients within a 3D‐printed platform. Human MSC spheroids are spatially directed to form cartilage–bone interfaces, enabling evaluation of regeneration without biochemical reagents and assessment of drug responses. This physiologically relevant, phase‐specific
Choi Y +11 more
europepmc +2 more sources
Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia. [PDF]
, 2003 BACKGROUND\ud \ud Mutations of the transforming growth factor beta (TGFbeta) receptor components ENDOGLIN and ALK-1 cause the autosomal dominant vascular disorder hereditary haemorrhagic telangiectasia (HHT).
Flanagan, J A +16 more
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Relationship of Liver X Receptors α and Endoglin Levels in Serum and Placenta with Preeclampsia. [PDF]
PLoS ONE, 2016 BACKGROUND:Liver X receptor alpha (LXRα) and endoglin have been postulated to play roles in trophoblast invasion and lipid metabolic disturbances.
Jing Wang +6 more
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Cells, 2023 Now that mechanical thrombectomy has substantially improved outcomes after large-vessel occlusion stroke in up to every second patient, futile reperfusion wherein successful recanalization is not followed by a favorable outcome is moving into focus ...
Axel Haarmann +7 more
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Soluble endoglin effects on membrane endoglin signaling in mouse aorta. [PDF]
, 2021 Charles University Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Author: Petra Doležálková Supervisor: prof. PharmDr. Petr Nachtigal, Ph.D.
Doležálková, Petra
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