Results 41 to 50 of about 13,041 (209)

Role of Endoglin in Fibrosis and Scleroderma [PDF]

, 2012
Fibrosis plays a role in many pathological conditions, among which is the autoimmune disease systemic sclerosis (SSc). SSc is characterized by fibrosis in the skin and internal organs, but the etiology remains to be elucidated. Transforming growth factor-β (TGF-β) is a key player in the fibrotic process, also in SSc.
Janita A, Maring, Maria, Trojanowska, Peter, ten Dijke   +2 more
openaire   +2 more sources

Endoglin haploinsufficiency promotes fibroblast accumulation during wound healing through Akt activation. [PDF]

PLoS ONE, 2013
Accurate regulation of dermal fibroblast function plays a crucial role in wound healing. Many fibrotic diseases are characterized by a failure to conclude normal tissue repair and the persistence of fibroblasts inside lesions.
Miguel Pericacho, Soraya Velasco, Marta Prieto, Elena Llano, José M López-Novoa, Alicia Rodríguez-Barbero   +5 more
doaj   +1 more source

Circulating endoglin concentration is not elevated in chronic kidney disease. [PDF]

PLoS ONE, 2011
Soluble endoglin, a TGF-β receptor, plays a key role in cardiovascular physiology. Whether circulating concentrations of soluble endoglin are elevated in CKD or underlie the high risk of cardiovascular death associated with chronic kidney disease (CKD ...
David M Charytan, Alexander M Helfand, Brian A MacDonald, Angeles Cinelli, Raghu Kalluri, Elisabeth M Zeisberg   +5 more
doaj   +1 more source

Membrane and Soluble Forms of Endoglin in Preeclampsia [PDF]

Current Molecular Medicine, 2013
Preeclampsia is a disease of high incidence in pregnant women which complicates pregnancy and may lead to the death of mother and baby. Preeclampsia is characterized by a series of clinical features such as hypertension and proteinuria associated with endothelial dysfunction. Although the causes of disease have not been elucidated, it has been reported
Oujo, Barbara, Pérez-Barriocanal, Fernando, Bernabéu, Carmelo, López-Novoa, José M.   +3 more
openaire   +3 more sources

Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling

Frontiers in Pharmacology, 2022
Background: Peritoneal fibrosis (PF) is an intractable complication in patients on long-term peritoneal dialysis (PD). Transforming growth factor-β (TGF-β) is a key pro-fibrogenic factor involved in PD-associated PF, and endoglin, as a coreceptor for TGF-
Qian Huang, Rui Xiao, Jing Lu, Yao Zhang, Liang Xu, Jie Gao, Jing Sun, Jing Sun, Haiping Wang, Haiping Wang   +9 more
doaj   +1 more source

Soluble Flt-1 and PlGF: new markers of early pregnancy loss? [PDF]

, 2011
Recent data have indicated a relationship between placental oxygen and angiogenic protein levels in the first trimester of normal pregnancies. Our objective was to investigate if maternal serum levels of angiogenic factors Soluble vascular endothelial ...
Michelle Swer, Muttukrishna, S, Suri, S, Jurkovic, Davor, Jamil, Amna, Swer, Michelle, Suri, Sangeeta, Sangeeta Suri, Jauniaux, E, Gangooly, Subrata, Gangooly, S, Calleja-Agius, Jean, Jamil, A, Amna Jamil, Ludlow, H, Muttukrishna, Shanthi, Jurkovic, D, Helen Ludlow, Davor Jurkovic, Calleja-Agius, J, Eric Jauniaux, Subrata Gangooly, Swer, M, Jean Calleja-Agius, Jauniaux, Eric R.M., Ludlow, Helen, Shanthi Muttukrishna   +26 more
core   +1 more source

Circulating soluble endoglin modifies the inflammatory response in mice. [PDF]

PLoS ONE, 2017
Inflammation is associated with every health condition, and is an important component of many pathologies such as cardiovascular diseases. Circulating levels of soluble endoglin have been shown to be higher in the serum of patients with cardiovascular ...
Laura Ruiz-Remolina, Claudia Ollauri-Ibáñez, Lucía Pérez-Roque, Elena Núñez-Gómez, Fernando Pérez-Barriocanal, José Miguel López-Novoa, Miguel Pericacho, Alicia Rodríguez-Barbero   +7 more
doaj   +1 more source

Ischemia Regulates Endoglin Expression in a Pig Skin Flap Model

McGill Journal of Medicine, 2020
Endoglin is a transmembrane protein that binds transforming growth factor b (TGF-b) with high affinity. It is thought to modulate TGF-b signaling and responses through interactions on cell surfaces with TGF-b receptors.
Toni Nimeh, Roya Haghighat-Mortazavi, Kayvan Khiabani, Noura Malek, B.Sc., Kevin Watters, Anie Philip   +5 more
doaj   +1 more source

BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses.

PLoS ONE, 2015
Endoglin is a type III TGFβ auxiliary receptor that is upregulated in endothelial cells during angiogenesis and, when mutated in humans, results in the vascular disease hereditary hemorrhagic telangiectasia (HHT).
Kira Young, Eric Tweedie, Barbara Conley, Jacquelyn Ames, MaryLynn FitzSimons, Peter Brooks, Lucy Liaw, Calvin P H Vary   +7 more
doaj   +1 more source

Transforming growth factor-beta receptor mutations and pulmonary arterial hypertension in childhood

, 2005
BACKGROUND: Pulmonary arterial hypertension (PAH) is a potentially fatal vasculopathy that can develop at any age. Adult-onset disease has previously been associated with mutations in BMPR2 and ALK-1.
Haworth, SG, Berger, R; id_orcid, Aldred, M A, Morrell, NW, Harrison, RE, Morrell, Nicholas W., Morrell, N W, Mache, CJ, Haworth, S G, Trembath, R C, Mache, Christoph J., Aldred, MA, Trembath, RC, Berger, Rolf, Aldred, Micheala A., Berger, R, Tulloh, R, Harrison, R E, Harrison, Rachel E., Haworth, Sheila G., Mache, C J, Trembath, Richard C., Tulloh, Robert   +22 more
core   +1 more source