Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.ABSTRACT TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly) syndrome is a rare, life‐threatening inflammatory condition linked to infections, neoplasms, and idiopathic multicentric Castleman disease. Interleukin (IL)‐6 inhibitors are the primary treatment, but refractory cases require alternatives. This
Serena Palmeri +10 more
wiley +1 more source
HHV-8 encoded LANA-1 alters the higher organization of the cell nucleus
Molecular Cancer, 2007 The latency-associated nuclear antigen (LANA-1) of Human Herpes Virus 8 (HHV-8), alternatively called Kaposi Sarcoma Herpes Virus (KSHV) is constitutively expressed in all HHV-8 infected cells.
G. Stuber +8 more
semanticscholar +1 more source
Human herpesvirus 8 – A novel human pathogen [PDF]
, 2005 In 1994, Chang and Moore reported on the latest of the gammaherpesviruses to infect humans, human herpesvirus 8 (HHV-8) [1]. This novel herpesvirus has and continues to present challenges to define its scope of involvement in human disease.
Edelman, Daniel C
core +2 more sources
Torque teno virus as a marker of immune status in immunocompromised patients: A systematic review
European Journal of Clinical Investigation, Volume 55, Issue 8, August 2025.Abstract Background Torque teno virus (TTV) is not known to cause disease in humans; however, chronic inflammatory conditions and immunosuppression states can favour TTV replication. This study aimed to verify the effectiveness of TTV as an immune biomarker.
Janaina B. Medina +8 more
wiley +1 more source
Risk Factors for Early Childhood Infection of Human Herpesvirus-8 in Zambian Children: The Role of Early Childhood Feeding Practices [PDF]
, 2014 Background—Human herpesvirus-8 (HHV-8) infection in early childhood is common throughout sub-Saharan Africa with prevalence increasing throughout childhood. Specific routes of transmission have not been clearly delineated, though HHV-8 is present in high
Crabtree, Kay L +6 more
core +1 more source
HIV-associated multi-centric Castleman’s disease with multiple organ failure: cuccessful treatment with rituximab [PDF]
, 2010 Introduction: Multicentric Castleman's Disease (MCD), a lymphoproliferative disorder associated with Human Herpes Virus-8 (HHV-8) infection, is increasing in incidence amongst HIV patients.
Agarwal, B +7 more
core
Sero-Epidemiological Studies on Human Herpes Virus-8 [PDF]
, 2005 Human herpes virus-8 (HHV-8) is a known carcinogenic agent. This report investigates five populations to determine if HHV-8 was associated with disease onset.
Hoffman, Linda J.
core
Long-term safety of siltuximab in patients with idiopathic multicentric Castleman disease: a prespecified, open-label, extension analysis of two trials. [PDF]
, 2020 BACKGROUND:Siltuximab is recommended by international consensus as a first-line treatment for idiopathic multicentric Castleman disease on the basis of durable efficacy and safety data.
Casper, Corey +6 more
core
Lack of Detection of Human Herpesvirus (HHV)-8 DNA in Lesional Skin of German Pemphigus Vulgaris and Pemphigus Foliaceus Patients [PDF]
, 2000 G. Bezold +3 more
openalex +1 more source
Human Herpesvirus 8 (HHV-8) Staining: A Savior in Early Kaposi Sarcoma. [PDF]
Cureus, 2023 Siddiqui F +4 more
europepmc +1 more source