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Hibernating Myocardium

New England Journal of Medicine, 1998
Heusch, Gerd. Hibernating Myocardium. Physiol. Rev. 78: 1055–1085, 1998. — Decreased myocardial contraction occurs as a consequence of a reduction in blood flow. The concept of hibernation implies a downregulation of contractile function as an adaptation to a reduction in myocardial blood flow that serves to maintain myocardial integrity and viability ...
Wijns W, Vatner SF, CAMICI , PAOLO
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Mammalian hibernation

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1990
Abstract In mammalian hibernation, the body temperature approaches that of the surroundings, allowing large savings in energy costs of basal metabolism and eliminating the need for heat production to compensate for heat loss. During entry into hibernation, heat production ceases while the body temperature set-point gradually decreases
J, Nedergaard, B, Cannon
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Ribosome Hibernation

Annual Review of Genetics, 2018
Protein synthesis consumes a large fraction of available resources in the cell. When bacteria encounter unfavorable conditions and cease to grow, specialized mechanisms are in place to ensure the overall reduction of costly protein synthesis while maintaining a basal level of translation.
Prossliner, Thomas   +3 more
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Heparinocytes and hibernation

Experientia, 1951
Trotz der stark herabgesetzten Schlagfrequenz des Herzens stellen sich beim winterschlafenden Igel keine Thromben ein. Die Menge der Heparinozyten oder Ehrlichschen Mastzellen ist denn auch beim Igel wahrend des Winterschlafs erhoht. Daraus, und aus dem histologischen Bild dieser Zellen, kann geschlossen werden, das die Heparinsekretion im Winterschlaf
P, SUOMALAINEN, R, HARMA
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The hibernating myocardium

American Heart Journal, 1989
The hibernating myocardium refers to resting LV dysfunction due to reduced coronary blood flow that can be partially or completely reversed by myocardial revascularization and/or by reducing myocardial oxygen demand. It is different from the stunned myocardium. Methods for its detection are not yet perfect.
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The hibernating myocardium

1996
Hibernating myocardium represents a chronic myocardial dysfunction at rest associated with reduced coronary perfusion. Although myocardial contraction is depressed, metabolic balance is maintained, myocytes remain viable and myocardial contraction can be restored with myocardial revascularization.
J, Leor, R A, Kloner
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Gluconeogenesis during hibernation and arousal from hibernation

Comparative Biochemistry and Physiology, 1967
Abstract 1. 1. In the ground squirrel, Citellus tridecemlineatus, liver glycogen and blood glucose decreased during hibernation. Two hours after arousal, liver glycogen remained low but blood glucose was normal. 2. 2. When incubated at 6°C, kidney cortex slices from hibernating animals had a greater capacity for gluconeogenesis from α ...
R F, Burlington, G J, Klain
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