Results 31 to 40 of about 990 (176)

Synthetic Strategy towards a Carbocyclic N‐Acetylneuraminic Acid

European Journal of Organic Chemistry, Volume 2022, Issue 27, July 21, 2022., 2022
A novel route towards a carbocyclic N‐acetylneuraminic acid mimic is presented. Although the route ran into difficulties in the final stage, it can still act as a useful guide towards future carbocyclic activity‐based probes for sialidases. Abstract In the study of glycosidases, a class of activity‐based probes (ABPs), that are carbocyclic mimics of ...
Pieter de Saint Aulaire, Jorin Hoogenboom, Michiel T. Uiterweerd, Han Zuilhof, Tom Wennekes   +4 more
wiley   +1 more source

Expanding the clinicopathological‐genetic spectrum of GNE myopathy by a Chinese neuromuscular centre

Journal of Cellular and Molecular Medicine, Volume 25, Issue 22, Page 10494-10503, November 2021., 2021
Abstract GNE myopathy is a heterogeneous group of ultrarare neuromuscular disorders caused by mutations in the GNE gene. An estimated prevalence of 1~21/1,000,000 leads to a deficiency of data and a lack of availability of samples to conduct clinical research on this neuromuscular disorder.
Kai‐Yue Zhang, Hui‐Qian Duan, Qiu‐Xiang Li, Yue‐Bei Luo, Fang‐Fang Bi, Kun Huang, Huan Yang   +6 more
wiley   +1 more source

UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) binds to alpha-actinin 1: novel pathways in skeletal muscle? [PDF]

PLoS ONE, 2008
BACKGROUND: Hereditary inclusion body myopathy (HIBM) is a rare neuromuscular disorder caused by mutations in GNE, the key enzyme in the biosynthetic pathway of sialic acid.
Shira Amsili, Hagit Zer, Stephan Hinderlich, Sabine Krause, Michal Becker-Cohen, Daniel G MacArthur, Kathryn N North, Stella Mitrani-Rosenbaum   +7 more
doaj   +1 more source

GNE myopathy: History, etiology, and treatment trials

Frontiers in Neurology, 2022
GNE myopathy is an ultrarare muscle disease characterized by slowly progressive muscle weakness. Symptoms typically start in early adulthood, with weakness and atrophy in the tibialis anterior muscles and with slow progression over time, which largely ...
Jeffrey Mullen, Khalid Alrasheed, Tahseen Mozaffar, Tahseen Mozaffar, Tahseen Mozaffar   +4 more
doaj   +1 more source

Description of Nuclear Structure Effects in Subbarrier Fusion by the Interacting Boson Model [PDF]

, 1997
Recent theoretical developments in using the Interacting Boson Model to describe nuclear structure effects in fusion reactions below the Coulomb barrier are reviewed. Methods dealing with linear and all orders coupling between the nuclear excitations and
A B Balantekin, Balantekin A B, Balantekin A B, Balantekin A B, Beckerman M, Iachello F, Kuyucak S, Kuyucak S, Leigh J R, S Kuyucak, Takigawa N   +10 more
core   +2 more sources

Probing anharmonic properties of nuclear surface vibration by heavy-ion fusion reactions [PDF]

, 1997
Describing fusion reactions between ^{16}O and ^{154}Dy and, between ^{16}O and ^{144}Sm by the $sd-$ and $sdf-$ interacting boson model, we show that heavy-ion fusion reactions are strongly affected by anharmonic properties of nuclear surface vibrations
Balantekin A B, Balantekin A B, Balantekin A B, Beckerman M, Dasgupta M, Gatenby R A, Hagino K, Hagino K, K Hagino, Morton C R, N Takigawa, S Kuyucak, Takigawa N   +12 more
core   +2 more sources

SU(3) realization of the rigid asymmetric rotor within the IBM [PDF]

, 1999
It is shown that the spectrum of the asymmetric rotor can be realized quantum mechanically in terms of a system of interacting bosons. This is achieved in the SU(3) limit of the interacting boson model by considering higher-order interactions between the
A. Arima, A. Arima, A. Arima, A. Arima, A. Arima, A. Bohr, A. E. L. Dieperink, A. E. L. Dieperink, A. Leviatan, A. Leviatan, A. S. Davydov, B. R. Judd, C. Bahri, D. R. Bes, F. Iachello, G. Vanden Berghe, H. Ui, J. Carvalho, J. N. Ginocchio, J. P. Draayer, J. P. Elliott, J. P. Elliott, J. P. Elliott, J. Wilets, K. Heyde, Liao Ji-zhi, Liao Ji-zhi, M. Sugita, N. V. Zamfir, Nadya A. Smirnova, O. Castaños, P. Rochford, P. Van Isacker, P. Van Isacker, Piet Van Isacker, R. F. Casten, T. Otsuka, Y. Leschber, Yuri F. Smirnov   +38 more
core   +5 more sources

Partial Dynamical Symmetry in the Symplectic Shell Model [PDF]

, 2001
We present an example of a partial dynamical symmetry (PDS) in an interacting fermion system and demonstrate the close relationship of the associated Hamiltonians with a realistic quadrupole-quadrupole interaction, thus shedding new light on this ...
A. Arima, A. Leviatan, A. Leviatan, A. Leviatan, A. Leviatan, A. Leviatan, Amiram Leviatan, C. Bahri, C. Bahri, D. Branford, D.J. Rowe, D.J. Rowe, D.J. Rowe, D.J. Rowe, D.R. Peterson, D.R. Tilley, E. Canetta, F. Ajzenberg-Selove, F. Arickx, F. Arickx, G. Rosensteel, G. Rosensteel, G. Rosensteel, G. Rosensteel, G. Rosensteel, I. Talmi, J. Deenen, J. Escher, J. Escher, J. Escher, J.D. Vergados, J.L. Ping, J.P. Draayer, J.P. Draayer, J.P. Draayer, J.P. Draayer, J.P. Draayer, J.P. Elliott, J.P. Elliott, Jutta Escher, K.T. Hecht, K.T. Hecht, K.T. Hecht, M.F. O’Reilly, N.D. Whelan, O. Castaños, O. Castaños, P. Raghavan, P. Van Isacker, P.M. Endt, R. Lopez, R.H. Spear, R.V. Jolos, R.V. Jolos, S.S. Avancini, T. Otsuka, W.J. Vermeer, Y. Akiyama, Y. Alhassid, Y. Suzuki   +59 more
core   +2 more sources

Glycoprotein hyposialylation gives rise to a nephrotic-like syndrome that is prevented by sialic acid administration in GNE V572L point-mutant mice. [PDF]

PLoS ONE, 2012
Mutations in the key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetyl-mannosamine kinase, result in distal myopathy with rimmed vacuoles (DMRV)/hereditary inclusion body myopathy (HIBM) in humans.
Mitutoshi Ito, Kazushi Sugihara, Tomoya Asaka, Tadashi Toyama, Toru Yoshihara, Kengo Furuichi, Takashi Wada, Masahide Asano   +7 more
doaj   +1 more source

A preclinical trial of sialic acid metabolites on distal myopathy with rimmed vacuoles/ hereditary inclusion body myopathy, a sugar-deficient myopathy: a review

Therapeutic Advances in Neurological Disorders, 2010
Distal myopathy with rimmed vacuoles (DMRV), also called hereditary inclusion body myopathy (hIBM), is a moderately progressive hereditary muscle disorder affecting young adults.
May Christine V. Malicdan, Satoru Noguchi, Ichizo Nishino   +2 more
doaj   +1 more source