Results 81 to 90 of about 63,611 (263)

ThiF‐Like Enzyme Chemistry in Primary and Secondary Metabolism

open access: yesChemBioChem, EarlyView.
ThiF‐like enzymes are a widespread protein family found in disparate biosynthetic pathways. They are unified by their use of an NTP to modify a carboxylate, generating an activated species prone to nucleophilic addition. This common intermediate is then targeted by diverse nucleophiles, including persulfide or amino acid side chains, to yield a variety
Keelie S. Butler   +2 more
wiley   +1 more source

Hidden Markov models applied to a subsequence of the Xylella fastidiosa genome

open access: yesGenetics and Molecular Biology, 2003
Dependencies in DNA sequences are frequently modeled using Markov models. However, Markov chains cannot account for heterogeneity that may be present in different regions of the same DNA sequence.
Silva Cibele Q. da
doaj  

Restricted Tweedie stochastic block models

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract The stochastic block model (SBM) is a widely used framework for community detection in networks, where the network structure is typically represented by an adjacency matrix. However, conventional SBMs are not directly applicable to an adjacency matrix that consists of nonnegative zero‐inflated continuous edge weights.
Jie Jian, Mu Zhu, Peijun Sang
wiley   +1 more source

meta-MEME: Motif-based hidden Markov models of protein families [PDF]

open access: bronze, 1997
William Noble Grundy   +3 more
openalex   +1 more source

A probabilistic diagnostic for Laplace approximations: Introduction and experimentation

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Many models require integrals of high‐dimensional functions: for instance, to obtain marginal likelihoods. Such integrals may be intractable, or too expensive to compute numerically. Instead, we can use the Laplace approximation (LA). The LA is exact if the function is proportional to a normal density; its effectiveness therefore depends on ...
Shaun McDonald, Dave Campbell
wiley   +1 more source

Convergence properties of dynamic mode decomposition for analytic interval maps

open access: yesCommunications on Pure and Applied Mathematics, EarlyView.
Abstract Extended dynamic mode decomposition (EDMD) is a data‐driven algorithm for approximating spectral data of the Koopman operator associated to a dynamical system, combining a Galerkin method with N$N$ functions and a quadrature method with M$M$ quadrature nodes.
Elliz Akindji   +3 more
wiley   +1 more source

Leakage risk assessment system for salt cavern hydrogen storage

open access: yesDeep Underground Science and Engineering, EarlyView.
Establishment of a leakage risk evaluation system for salt cavern hydrogen storage reservoirs using the entropy weight method plus two‐dimensional cloud modeling approach. Abstract Salt cavern hydrogen storage (SCHS) is an important component of large‐scale underground hydrogen storage, with advantages such as large hydrogen storage capacity and ...
Weizheng Bai   +4 more
wiley   +1 more source

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