Results 61 to 70 of about 569,916 (267)

Hierarchical estimation as a basis for hierarchical forecasting [PDF]

IMA Journal of Management Mathematics, 2006
In inventory management, hierarchical forecasting (HF) is a hot issue : families of items are formed for which total demand is forecasted; total forecast then is broken up to produce forecasts for the individual items.Since HF is a complicated procedure, analytical results are hard to obtain; consequently, most literature is based on simulations and ...
Strijbosch, L.W.G., Heuts, R.M.J., Moors, J.J.A.   +2 more
openaire   +5 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Chiral dual-annihilator model for controllable photon upconversion and multi-dimensional optical modulation

Nature Communications
Triplet-triplet annihilation photon upconversion seeks efficient conversion of low-energy photons to high-energy emission. However, the triplet-triplet annihilation photon upconversion system faces limitations in emission gamut because efficient triplet ...
Honghan Ji, Zhiwang Luo, Xuefeng Yang, Xue Jin, Tonghan Zhao, Pengfei Duan   +5 more
doaj   +1 more source

Hierarchical coded caching [PDF]

2014 IEEE International Symposium on Information Theory, 2014
Caching of popular content during off-peak hours is a strategy to reduce network loads during peak hours. Recent work has shown significant benefits of designing such caching strategies not only to deliver part of the content locally, but also to provide coded multicasting opportunities even among users with different demands.
Nikhil Karamchandani, Urs Niesen, Mohammad Ali Maddah-Ali, Suhas N. Diggavi   +3 more
openaire   +3 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Reversible three-dimensional chirality continuum enabled by luminomagnetic superstructure in gel

Nature Communications
Chirality continuum is crucial for advancing fundamental theories - spanning symmetry breaking and topological invariants - and for developing functional materials with tunable chiroptical, spintronic, and magnetic properties.
Ki-Jae Jeong, Lulu Zhang, Fulin Jia, Fenglian Qi, Jianxiao Gong, Zhiyong Tang   +5 more
doaj   +1 more source

Hierarchical Leak Detection and Localization Method in Natural Gas Pipeline Monitoring Sensor Networks

Sensors, 2011
In light of the problems of low recognition efficiency, high false rates and poor localization accuracy in traditional pipeline security detection technology, this paper proposes a type of hierarchical leak detection and localization method for use in ...
Ning Yu, Renjian Feng, Jiangwen Wan, Yinfeng Wu, Yang Yu   +4 more
doaj   +1 more source

Codes with hierarchical locality [PDF]

2015 IEEE International Symposium on Information Theory (ISIT), 2015
In this paper, we study the notion of {\em codes with hierarchical locality} that is identified as another approach to local recovery from multiple erasures. The well-known class of {\em codes with locality} is said to possess hierarchical locality with a single level.
Birenjith Sasidharan, Gaurav Kumar Agarwal, P. Vijay Kumar   +2 more
openaire   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Structural Design and Applications of Chiral Perovskites

Energy Material Advances
Chiral perovskites, due to their unique optical and electronic properties, show broad application prospects in fields such as photonics, spintronics, and photodetection.
Ze Wang, Guanghan Zhao, Hong Zhang, Huiqiong Zhou, Zhiyong Tang   +4 more
doaj   +1 more source