Results 121 to 130 of about 98,895 (273)

Hierarchical reinforcement learning with central pattern generator for enabling a quadruped robot simulator to walk on a variety of terrains

Scientific Reports
We present a data-driven deep reinforcement learning (DRL) method for the optimization of a hierarchically structured control policy that includes the central pattern generator.
Toshiki Watanabe, Akihiro Kubo, Kai Tsunoda, Tatsuya Matsuba, Shintaro Akatsuka, Yukihiro Noda, Hiroaki Kioka, Jin Izawa, Shin Ishii, Yutaka Nakamura   +9 more
doaj   +1 more source

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

A trajectory planning and tracking method based on deep hierarchical reinforcement learning

Journal of Intelligent and Connected Vehicles
To improve the driving efficiency of unmanned vehicles in a complex urban traffic flow environment and the safety and passenger comfort of vehicles when changing lanes, we propose a hierarchical reinforcement learning (HRL)-based vehicle trajectory ...
Jiajie Zhang, Bao-Lin Ye, Xin Wang, Lingxi Li, Bo Song   +4 more
doaj   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Hierarchical Decision Making-Based Intelligent Game Confrontation on UAV Swarm

Aerospace
To address the challenge of decision making in close-range air combat for fixed-wing unmanned air vehicle (UAV) swarms, this paper proposes a distributed Hierarchical Cooperative Soft Actor-Critic with maximum entropy (HC-SAC) framework.
Guannan Chang, Siyuan Ren, Shuna Zhang, Xiaofeng Zhang   +3 more
doaj   +1 more source

Modification Strategies of Carbon‐Based Electrodes From Structural Regulation to Multifunctional Integration

Advanced Science, EarlyView.
Tracing the evolution from structural regulation to multifunctional integration, this paper systematically analyzes modification strategies for carbon‐based electrodes. It evaluates how element doping, surface functionalization, and composite material design affect the electrode performance, and offers perspectives on future applications and challenges
Yunlei Wang, Shitao Dou, Yifan Wu, Mingguang Wang, Taibin Wu   +4 more
wiley   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Dynamic AI-Enhanced Therapeutic Framework for Precision Medicine Using Multi-Modal Data and Patient-Centric Reinforcement Learning

IEEE Access
The integration of Artificial Intelligence (AI) and Machine Learning (ML) is revolutionizing precision medicine by enabling the customization of therapeutic strategies to individual patient profiles.
R. Gayathri, S. K. B. Sangeetha, R. Sangeetha, G. Leena Rosalind Mary, Sandeep Kumar Mathivanan, Usha Moorthy   +5 more
doaj   +1 more source

Structure‐Dependent Resonant Frequency Engineering of Textile Tactile Sensors Toward Rapid and Precise Braille Recognition Surpassing Human Sensation

Advanced Science, EarlyView.
A resonant frequency engineering strategy is proposed to modulate the sensibility of piezoresistive textile‐based tactile sensor. It achieves simultaneous detection of static pressure and dynamic vibrations across an unprecedented bandwidth of 5–600 Hz, surpassing human sensation, therefore enables rapid and precise braille recognition.
Xianhong Zheng, Runrun Zhang, Yu Shi, Zhao Zhang, Guiyang Li, Zhengliang Shang, Xin Liu, Fan Zhao, Sheng Hu, Ran Xu, Shuai Wang, Zhiqi Zhao, Zhi Liu, Lihua Zou, Xu Han, Zongqian Wang, Wei Huang, Gengzhi Sun   +17 more
wiley   +1 more source

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

Advanced Science, EarlyView.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He, Yunpei Xu, Liqing Ding, Hong‐Dong Li, Yaohang Li, Shaokai Wang   +5 more
wiley   +1 more source