Results 51 to 60 of about 195,286 (257)

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Determination of a Differential Item Functioning Procedure Using the Hierarchical Generalized Linear Model

open access: yesSAGE Open, 2012
The aim of this research is to compare the result of the differential item functioning (DIF) determining with hierarchical generalized linear model (HGLM) technique and the results of the DIF determining with logistic regression (LR) and item response ...
Tülin Acar
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Decoding Voluntary Movement of Single Hand Based on Analysis of Brain Connectivity by Using EEG Signals

open access: yesFrontiers in Human Neuroscience, 2018
Research about decoding neurophysiological signals mainly aims to elucidate the details of human motion control from the perspective of neural activity.
Ting Li   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Modernizing use of regression models in physics education research: A review of hierarchical linear modeling

open access: yesPhysical Review Physics Education Research, 2019
[This paper is part of the Focused Collection on Quantitative Methods in PER: A Critical Examination.] Physics education researchers (PER) often analyze student data with single-level regression models (e.g., linear and logistic regression).
Ben Van Dusen, Jayson Nissen
doaj   +1 more source

Influence of Leaders' Psychological Capital on Their Followers: Multilevel Mediation Effect of Organizational Identification

open access: yesFrontiers in Psychology, 2017
We investigated the relationships between leaders' and their followers' psychological capital and organizational identification in a Chinese community.
Qishan Chen   +4 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

Trajectories of sleep changes during the acute phase of traumatic brain injury: A 7-day actigraphy study

open access: yesJournal of the Formosan Medical Association, 2013
To examine trajectories of change in sleep during the acute phase of traumatic brain injury (TBI), and whether specific demographic and disease characteristics predicted the initial levels of sleep and the trajectories of change in sleep parameters ...
Hsiao-Yean Chiu   +4 more
doaj   +1 more source

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