Results 71 to 80 of about 1,685,765 (286)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

The use of random-effects models to identify health care center-related characteristics modifying the effect of antipsychotic drugs

open access: yesClinical Epidemiology, 2017
Clementine Nordon,1 Constance Battin,1 Helene Verdoux,2 Josef Maria Haro,3 Mark Belger,4 Lucien Abenhaim,1 Tjeerd Pieter van Staa5 On behalf of the IMI GetReal WP2 Group 1Epidemiological Research, Analytica LASER, Paris, 2Population Health Research ...
Nordon C   +6 more
doaj  

Modeling Response Time and Responses in Multidimensional Health Measurement

open access: yesFrontiers in Psychology, 2019
This study explored calibrating a large item bank for use in multidimensional health measurement with computerized adaptive testing, using both item responses and response time (RT) information.
Chun Wang, David J. Weiss, Shiyang Su
doaj   +1 more source

ОЦІНКА ДІЯЛЬНОСТІ ПІДПРИЄМСТВ МІСТ ТА РАЙОНІВ ЗАКАРПАТСЬКОЇ ОБЛАСТІ МЕТОДОМ АНАЛІЗУ ІЄРАРХІЙ

open access: yesInternational Journal of Innovative Technologies in Economy, 2020
The article assesses the results of activity of enterprises of cities and districts of Zakarpattya region with the use of the Saati method. The conducted studies on this method allowed to obtain an assessment of the activities of enterprises by ...
Шитікова Т. В.   +1 more
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

Spectral problem of block-rectangular hierarchical matrices

open access: yes, 2010
The spectral problem for matrices with a block-hierarchical structure is often considered in context of the theory of complex systems. In the present article, a new class of matrices with a block-rectangular non-symmetric hierarchical structure is ...
Gutkin, B., Osipov, V. Al.
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Landbird trends in protected areas using time‐to‐event occupancy models

open access: yesEcosphere, 2019
Global populations of wildlife are affected by human activity, land cover change, and climate change. Long‐term monitoring programs across large spatial scales are required to understand how these and other factors affect wildlife populations.
Jesse Whittington   +9 more
doaj   +1 more source

A Hierarchical and Abstraction-Based Blockchain Model

open access: yesApplied Sciences, 2019
In the nine years since its launch, amid intense research, scalability is always a serious concern in blockchain, especially in case of large-scale network generating huge number of transaction-records. In this paper, we propose a hierarchical blockchain
Swagatika Sahoo   +3 more
doaj   +1 more source

Hierarchical Coding for Distributed Computing

open access: yes, 2018
Coding for distributed computing supports low-latency computation by relieving the burden of straggling workers. While most existing works assume a simple master-worker model, we consider a hierarchical computational structure consisting of groups of ...
Lee, Kangwook   +4 more
core   +1 more source

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