Results 81 to 90 of about 33,003,501 (342)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

dalmatian: A Package for Fitting Double Hierarchical Linear Models in R via JAGS and nimble

Journal of Statistical Software, 2021
Traditional regression models, including generalized linear mixed models, focus on understanding the deterministic factors that affect the mean of a response variable.
Simon Bonner, Han-Na Kim, David Westneat, Ariane Mutzel, Jonathan Wright, Matthew Schofield   +5 more
doaj   +1 more source

Dynamic Hierarchical Factor Models [PDF]

SSRN Electronic Journal, 2011
AbstractThis paper uses multilevel factor models to characterize within- and between-block variations as well as idiosyncratic noise in large dynamic panels. Block-level shocks are distinguished from genuinely common shocks, and the estimated block-level factors are easy to interpret. The framework achieves dimension reduction and yet explicitly allows
Emanuel Moench, Serena Ng, Simon M. Potter   +2 more
openaire   +4 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Key Habitat and Predatory Influences on the Community- and Species-Level Population Dynamics of Spring-Breeding Amphibian Larvae Within a Remnant Tupelo-Cypress Wetland

Hydrobiology
Understanding the factors influencing amphibian populations is essential for effective freshwater conservation, particularly for species with biphasic life histories.
Jacob M. Hutton, Robin W. Warne
doaj   +1 more source

Hierarchical Variational Models

CoRR, 2015
Appears in International Conference on Machine Learning ...
Rajesh Ranganath, Dustin Tran, David M. Blei   +2 more
openaire   +4 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A class of admissible estimators of multiple regression coefficient with an unknown variance

Statistical Theory and Related Fields, 2020
Suppose that we observe ${\boldsymbol y} \mid {\boldsymbol \theta },\ \tau \sim N_p({\boldsymbol X}{\boldsymbol \theta },\tau ^{-1}{\boldsymbol I}_p) $, where ${\boldsymbol \theta } $ is an unknown vector with unknown precision τ.
Chengyuan Song, Dongchu Sun
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Large positive ecological changes of small urban greening actions

Ecological Solutions and Evidence, 2023
The detrimental effects of environmental change on human and non‐human diversity are acutely manifested in urban environments. While urban greenspaces are known to mitigate these effects and support functionally diverse ecological communities, evidence ...
Luis Mata, Amy K. Hahs, Estibaliz Palma, Anna Backstrom, Nikolas Johnston, Tyler King, Ashley R. Olson, Christina Renowden, Tessa R. Smith, Blythe Vogel, Samantha Ward   +10 more
doaj   +1 more source