Results 91 to 100 of about 2,771,947 (386)

Automatic Code Generation From UML State Chart Diagrams

open access: yesIEEE Access, 2019
The fact that event driven systems can be modeled and implemented using unified modeling language (UML) state chart diagrams has led to the development of code generation tools.
Sunitha E. V., Philip Samuel
doaj   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

open access: yesMolecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova   +26 more
wiley   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

open access: yesMolecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi   +12 more
wiley   +1 more source

The Identity Politics of Qualitative Research. A Discourse Analytic Inter-text

open access: yesForum: Qualitative Social Research, 2006
We intend this paper to be read as an inter-text between selected FQS articles, which in one way or another engage in the identity politics of qualitative research, and the broader discussion of quality in the social sciences. Subjecting those texts to a
Pascal Dey, Julia C. Nentwich
doaj  

"Doubled" generalized Landau-Lifshiz hierarchies and special quasigraded Lie algebras

open access: yes, 2004
Using special quasigraded Lie algebras we obtain new hierarchies of integrable nonlinear vector equations admitting zero-curvature representations. Among them the most interesting is extension of the generalized Landau-Lifshitz hierarchy which we call ...
Bolsinov A   +18 more
core   +2 more sources

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

The hierarchy quorum sensing network in Pseudomonas aeruginosa

open access: yesProtein & Cell, 2014
Pseudomonas aeruginosa causes severe and persistent infections in immune compromised individuals and cystic fibrosis sufferers. The infection is hard to eradicate as P. aeruginosa has developed strong resistance to most conventional antibiotics.
Jasmine Lee, Lian-zhu Zhang
semanticscholar   +1 more source

The integrable hierarchy constructed from a pair of KdV-type hierarchies and its associated $W$ algebra

open access: yes, 1994
For any two arbitrary positive integers `$n$' and `$m$', using the $m$--th KdV hierarchy and the $(n+m)$--th KdV hierarchy as building blocks, we are able to construct another integrable hierarchy (referred to as the $(n,m)$--th KdV hierarchy).
A. Polyakov   +19 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

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