Results 141 to 150 of about 126,163 (218)

A warming-yang herbal decoction protects against high-altitude hypoxia-induced osteoblast injury through modulation of HIF-1 signaling. [PDF]

Front Pharmacol
Liu X, Qi Y, Zhao R, Jia B, Lei X, Li H, Wang D, Zhang H, Wang W, Song Z.   +9 more
europepmc   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

Computational biological analysis reveals that HIF-1 and FoxO signaling pathways influence cognitive impairment in patients with depression. [PDF]

Transl Psychiatry
Zhuo C, Zhang Y, Zhang Q, Yang L, Chen X, Ma X, Li R, Wang L, Tian H, Mao F.   +9 more
europepmc   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

HIF-1 attenuates high-fiber diet-mediated proliferation and stemness of colonic epithelium. [PDF]

Gut Microbes
Ribeiro Castro P, Corrêa RO, Sérvulo Cruz Angelim MK, de Rezende Rodovalho V, Font Fernandes M, Dias Nirello V, Dos Santos Pereira Gomes AB, de Souza Felipe J, Passarielo Pral L, de Oliveira S, Rodrigues PB, Fachi JL, Reis-de-Oliveira G, Smith BJ, Carregari VC, Shealy NG, Shelton C, Martins-de-Souza D, Moraes-Vieira PM, Xavier Byndloss M, Varga-Weisz P, Ramirez Vinolo MA.   +21 more
europepmc   +1 more source

Photodynamic Biomimetic Nanoparticles Accelerate Tumor Vascular Normalization Initiation

Exploration, EarlyView.
Platelet‐mimetic IA@PM integrates apatinib‐driven vascular normalization with ICG‐mediated photodynamic therapy, creating a self‐amplifying vascular normalization therapy (VNT)–photodynamic therapy (PDT) cycle that accelerates the onset of the vascular normalization window and potentiates antitumor treatment.
Yufei Liu, Changheng Xie, Yanfeng Huang, Ting Wang, Shi Du, Hui Xiong, Jing Yao   +6 more
wiley   +1 more source

Epitranscriptomic regulation of HIF-1: bidirectional regulatory pathways. [PDF]

Mol Med
Benak D, Alanova P, Holzerova K, Chalupova M, Opletalova B, Kolar F, Pavlinkova G, Hlavackova M.   +7 more
europepmc   +1 more source

Resveratrol Ameliorates Allergic Rhinitis by Activating SIRT1 to Disrupt the Mitochondrial ROS‐Inflammation Vicious Cycle

Flavour and Fragrance Journal, EarlyView.
This study demonstrates that resveratrol alleviates allergic rhinitis by activating SIRT1, thereby disrupting the mitochondrial ROS‐inflammatory cycle, improving mitochondrial function, promoting anti‐inflammatory M2 macrophage polarisation, and reducing epithelial oxidative damage.
Xinyu Zhou, Yi Yue, Wenwen Qi, Wenqing Zhu, Xinran Liu, Rongcui Sui, Xuanchen Zhou   +6 more
wiley   +1 more source

Elevated VAMP8 expression promotes cervical cancer progression by enhancing autophagy via HIF-1 pathway. [PDF]

BMC Med
Wang Y, Wu D, Gai J, Cai Y, Hua K, Zhu Z, Xin W.   +6 more
europepmc   +1 more source

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source