Results 51 to 60 of about 325,078 (261)

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Age and Cardiovascular Risk Attributable to Apolipoprotein B, Low‐Density Lipoprotein Cholesterol or Non‐High‐Density Lipoprotein Cholesterol

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundHigher concentrations of the apolipoprotein B (apoB) lipoproteins increase the risk of cardiovascular disease. However, whether the risk associated with apoB lipoproteins varies with age has not been well examined.
Allan D. Sniderman, Shofiqul Islam, Matthew McQueen, Michael Pencina, Curt D. Furberg, George Thanassoulis, Salim Yusuf   +6 more
doaj   +1 more source

Protein and cell therapy for lecithin-cholesterol acyltransferase (LCAT) deficiency [PDF]

, 2009
Lecithin-cholesterol acyltransferase (LCAT) is an enzyme principally secreted by the liver into the circulation where it esterifies cholesterol and plays a key role in high- density lipoprotein (HDL) metabolism. In familial and acquired (liver disease)
Low, J K, Low, J.K.
core  

A Bivariate Genome-Wide Approach to Metabolic Syndrome STAMPEED Consortium [PDF]

, 2010
OBJECTIVE The metabolic syndrome (MetS) is defined as concomitant disorders of lipid and glucose metabolism, central obesity, and high blood pressure, with an increased risk of type 2 diabetes and cardiovascular disease.
O'Reilly, Paul F., David J. Couper, Marjo-Riitta Jarvelin, Mathias, Rasika A., Sun, Y. V., Becker, DM, Zhang, Q., Psaty, Bruce M., Dhananjay Vaidya, Assimes, Themistocles L., Rotter, Jerome I, Cashell Jaquish, Becker, LC, McCarthy, Mark I, Boerwinkle, E., Franceschini, Nora, O'Reilly, P. F., O'Reilly, Paul F, Feitosa, MF, Hartikainen, A.-L., Yanek, L., Knowles, JW, Bruce M. Psaty, Becker, Diane M, Mathias, RA, Lewis C. Becker, Goodarzi, Mark O., Kardia, Sharon LR, Glazer, NL, Themistocles L. Assimes, Kraja, Aldi T, Couper, D. J., Mathias, Rasika A, Couper, DJ, Kardia, SL, Kullo, I. J., Rasika A. Mathias, Province, Michael A., Guo Li, Borecki, IB, Absher, Devin, Borecki, Ingrid B., Chakravarti, A, Iribarren, C., Yanek, Lisa, Kari E. North, Jaquish, Cashell, O’Reilly, Paul F, Sovio, U., Becker, D. M., Sun, Yan V, Kraja, AT, Paul F. O’Reilly, Yii-Der Ida Chen, Lisa Yanek, Vaidya, D., Quertermous, Thomas, Chen, Yii-Der Ida, Leena Palotie, Sun, Yan V., Boerwinkle, Eric, Aldi T. Kraja, Goodarzi, Mark O, Pankow, JS, Talin Haritunians, Psaty, Bruce M, Palotie, L., Boerwinkle, E, Zhang, Q, Becker, L. C., Kral, Brian, Sovio, U, Feitosa, Mary F., Haritunians, T., North, Kari E., Haritunians, Talin, Brian Kral, Quertermous, T., Chen, Y.-d. I., Hartikainen, Anna-Liisa, Feitosa, Mary F, Chakravarti, A., Jarvelin, Marjo-Riitta, Hartikainen, AL, Mark O. Goodarzi, Diane M. Becker, Chakravarti, Aravinda, Sharon L.R. Kardia, Mary F. Feitosa, Palotie, L, Couper, David J., Anna-Liisa Hartikainen, Borecki, I. B., Nora Franceschini, Jarvelin, MR, North, Kari E, Knowles, Joshua W, Pankow, James S, Jerome I. Rotter, Couper, David J, Franceschini, N., McCarthy, M. I., Iribarren, C, Psaty, BM, Yanek, L, Vaidya, Dhananjay, Psaty, B. M., Kral, B, Becker, Lewis C, Kral, B., Michael A. Province, Ingrid B. Borecki, Chen, YD, Goodarzi, M. O., Glazer, N. L., Becker, Lewis C., Palotie, Leena, Jaquish, C., Kraja, Aldi T., Glazer, Nicole L, Kullo, IJ, Thomas Quertermous, Kullo, Iftikhar J, Joshua W. Knowles, Carlos Iribarren, Zhang, Qunyuan, Quertermous, T, Ulla Sovio, Li, Guo, Haritunians, T, Mathias, R. A., Jarvelin, M.-r., Sovio, Ulla, Qunyuan Zhang, Iftikhar J. Kullo, Province, Michael A, Rotter, J. I., Pankow, James S., Province, MA, McCarthy, MI, James S. Pankow, Knowles, J. W., Borecki, Ingrid B, Li, G, Eric Boerwinkle, Becker, Diane M., Kardia, Sharon L. R., Glazer, Nicole L., O'Reilly, PF, Sun, YV, North, K. E., Li, G., Mark I. McCarthy, Absher, D, Iribarren, Carlos, Vaidya, D, Absher, D., Feitosa, M. F., Franceschini, N, Aravinda Chakravarti, Knowles, Joshua W., Assimes, Themistocles L, Yan V. Sun, Kardia, S. L. R., Pankow, J. S., Rotter, Jerome I., Assimes, TL, Devin Absher, McCarthy, Mark I., North, KE, Assimes, T. L., Goodarzi, MO, Province, M. A., Jaquish, C, Nicole L. Glazer, Rotter, JI, Kraja, A. T., Kullo, Iftikhar J.   +177 more
core   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Serum LDL- and HDL-cholesterol determined by ultracentrifugation and HPLC

Journal of Lipid Research, 2011
Simple and precise methods for LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) measurements are essential for assessment of cardiovascular disease (CVD) risks and for lipid and lipoprotein studies.
Jun Dong, Hanbang Guo, Ruiyue Yang, Hongxia Li, Shu Wang, Jiangtao Zhang, Wenxiang Chen   +6 more
doaj   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio associated with psoriasis: a cross-sectional study

Frontiers in Medicine
ObjectiveIndividuals with psoriasis face significant physiological and psychological burdens, and their compliance and satisfaction with medication regimens are alarmingly low.
Xinyan Liu, Keou Li, Tingxuan Huang, Hongfeng Tang   +3 more
doaj   +1 more source

Urinary cholesterol: its association with a macromolecular protein- lipid complex [PDF]

, 1984
The cholesterol-containing complexes in the urine of normal subjects and patients with diseases accompanied by hyperexcretion of urinary cholesterol were characterized. In normal subjects, the major portion of the recovered urinary cholesterol was eluted
Jüngst, Dieter, Siess, E., Weiser, H., Karl, Hans Josef   +3 more
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