Results 251 to 260 of about 422,572 (333)

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

Efficacy and Safety of High-Intensity Interval Training in a Patient With Acute Lymphocytic Leukemia Receiving Consolidation Chemotherapy: A Case Report. [PDF]

Cureus
Hanajima W, Hirano Y, Takeda N, Nagafusa T, Yamauchi K.   +4 more
europepmc   +1 more source

A CMTM6 Nanobody Overcomes EGFR‐TKI Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Overcoming EGFR‐TKI resistance remains a critical challenge in NSCLC treatment. This study identifies CMTM6 as a key regulator of EGFR stability and demonstrates that a novel anti‐CMTM6 nanobody disrupts the CMTM6‐EGFR interaction. Targeting CMTM6 restores EGFR degradation, suppresses tumor growth, and confers therapeutic benefit in both CDX and PDX ...
Lu Xia, Jichuan Wang, Hui Xue, Haimeng Li, Qinghua Li, Sen Qin, Chunyu Yu, Yanhua Liu, Yu Gao, Lingyun Li, Sudun Guan, Enrun Zheng, Feiya Suo, Lin He, Yongsheng Wang, Wenling Han, Yongfeng Shang, Yong Geng, Luyang Sun   +18 more
wiley   +1 more source

Effects of high-intensity interval training on aerobic and anaerobic capacity in olympic combat sports: a systematic review and meta-analysis. [PDF]

Front Physiol
Yue F, Wang Y, Yang H, Zhang X.
europepmc   +1 more source

0111 : Role of endoplasmic reticulum stress in the deleterious cardiovascular consequences of chronic intermittent hypoxia. Beneficial effects of high-intensity interval training

, 2015
Guillaume Bourdier, Claire Arnaud, Elise Bélaidi-Corsat, Patrice Flore, Hervé Sanchez   +4 more
openalex   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Effects of high-intensity interval training on executive functions and IGF-1 levels in sedentary young women: a randomized controlled trial. [PDF]

Front Sports Act Living
Jimenez-Roldán MJ, Sañudo Corrales B, Carrasco Páez L.   +2 more
europepmc   +1 more source

Genetic Deconvolution of Embryonic and Maternal Cell‐Free DNA in Spent Culture Medium of Human Preimplantation Embryo Through Deep Learning

Advanced Science, EarlyView.
DECENT is a deep learning method that enhances noninvasive preimplantation genetic testing by accurately reconstructing embryonic copy number variations (CNVs) from cell‐free DNA in spent embryo culture media. By mitigating maternal contamination, DECENT improves diagnostic accuracy, even with high contamination levels, offering a reliable, noninvasive
Zhenyi Zhang, Jie Qiao, Yidong Chen, Peijie Zhou   +3 more
wiley   +1 more source

Effects of high-intensity interval training and moderate-intensity continuous training on mitochondrial dynamics in human skeletal muscle. [PDF]

Front Physiol
Li Y, Zhao W, Yang Q.
europepmc   +1 more source

Comparison of Different Forms of Exercise Training in Patients With Cardiac Disease: Where Does High-Intensity Interval Training Fit?

, 2016
Mathieu Gayda, Paula Aver Bretanha Ribeiro, Martin Juneau, Anil Nigam   +3 more
openalex   +1 more source