Results 91 to 100 of about 1,504,154 (294)
Synthesis of Di-Tert-Butyldicyclohexyl-18-Crown-6 and Its Extraction of Strontium
He huaxue yu fangshe huaxue90Sr(T1/2=28.9 a) is a highly toxic nuclide with high heat release and strong exothermic properties, and the content of 90Sr in radioactive waste must be accurately measured before disposal.
WANG Jing
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
Low-Power Subgraph Isomorphism at the Edge Using FPGAs
IEEE AccessSubgraph matching is a significant problem in several fields, including like social network analysis, chemical compound search, and fraud detection. While current solutions using CPU, graphics processing units (GPUs), and data center field-programmable ...
Roberto Bosio +5 more
doaj +1 more source
, 2019 Hardware synthesis is a general term used to refer to the processes involved in automatically generating a hardware design from its specification. High-level synthesis (HLS) could be defined as the translation from a behavioral description of the intended hardware circuit into a structural description similar to the compilation of programming languages
openaire +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Domain Specific Abstractions for the Development of Fast-by-Construction Dataflow Codes on FPGAs
ChipsFPGAs are popular in many fields but have yet to gain wide acceptance for accelerating HPC codes. A major cause is that whilst the growth of High-Level Synthesis (HLS), enabling the use of C or C++, has increased accessibility, without widespread ...
Nick Brown
doaj +1 more source
Separation Logic for High-level Synthesis
, 2017 High-level synthesis (HLS) promises a significant shortening of the digital hardware design cycle by raising the abstraction level of the design entry to high-level languages such as C/C++. However, applications using dynamic, pointer-based data structures remain difficult to implement well, yet such constructs are widely used in software.
openaire +3 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source