Results 61 to 70 of about 3,164,376 (236)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

GAHLS: an optimized graph analytics based high level synthesis framework. [PDF]

Sci Rep, 2023
Xiao Y, Nazarian S, Bogdan P.
europepmc   +1 more source

High Level Synthesis in ASP [PDF]

, 1986
Abstract : The purpose of the Advanced Silicon complier in Prolog project is to synthesize high-quality VLSI layouts from high-level specifications. The ASP system consists of two major components. The low-level part produces masks from functional blocks containing logic equations.
openaire   +2 more sources

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

EXTEND-L : an input language for extensible register transfer compilation [PDF]

, 1988
This report discusses the model and input language for EXTEND, a synthesis system that permits extensible register transfer synthesis. EXTEND-L fills the need for a language that bridges the gap between existing behavioral input descriptions, which are ...
Dutt, Nikil D., Gajski, Daniel D.
core  

High-Level Synthesis Design of Scalable Ultrafast Ultrasound Beamformer With Single FPGA. [PDF]

IEEE Trans Biomed Circuits Syst, 2023
Kou Z, You Q, Kim J, Dong Z, Lowerison MR, Sekaran NVC, Llano DA, Song P, Oelze ML.   +8 more
europepmc   +1 more source

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source

Enhanced chimp optimization algorithm for high level synthesis of digital filters. [PDF]

Sci Rep, 2022
Kaur M, Kaur R, Singh N.
europepmc   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Extending High-Level Synthesis for Task-Parallel Programs. [PDF]

Proc Annu IEEE Symp Field Program Cust Comput Mach, 2021
Chi Y, Guo L, Lau J, Choi YK, Wang J, Cong J.   +5 more
europepmc   +1 more source