Results 41 to 50 of about 4,365,462 (264)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

High-Order Finite Difference Hermite Weighted Essentially Nonoscillatory Method for Convection–Diffusion Equations

open access: yesMathematical and Computational Applications
A kind of finite difference Hermite WENO (HWENO) method is presented in this paper to deal with convection-dominated convection-diffusion equations in uniform grids.
Yabo Wang, Hongxia Liu
doaj   +1 more source

Distributed Non-Convex Input-Constrained Consensus Problem for High-Order Discrete-Time Multi-Agent Systems Subject to Switching Topologies, and Time Delays

open access: yesIEEE Access, 2019
In this paper, a distributed consensus problem is considered for high-order discrete-time multi-agent systems subject to non-convex input constraints and switching topologies.
Hongqiu Zhu, Yaozhong Wang, Pei Li
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Spatial-Temporal Contextual Aggregation Siamese Network for UAV Tracking

open access: yesDrones
In recent years, many studies have used Siamese networks (SNs) for UAV tracking. However, there are two problems with SNs for UAV tracking. Firstly, the information sources of the SNs are the invariable template patch and the current search frame.
Qiqi Chen   +4 more
doaj   +1 more source

High Order Side-Channel Security for Elliptic-Curve Implementations

open access: yesTransactions on Cryptographic Hardware and Embedded Systems, 2022
Elliptic-curve implementations protected with state-of-the-art countermeasures against side-channel attacks might still be vulnerable to advanced attacks that recover secret information from a single leakage trace.
Sonia Belaïd, Matthieu Rivain
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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