Results 161 to 170 of about 317,795 (294)

Democratising high performance computing for bioinformatics through serverless cloud computing: A case study on CRISPR-Cas9 guide RNA design with Crackling Cloud. [PDF]

PLoS Comput Biol
Bradford J, Joy D, Winsen M, Meurant N, Wilkins M, Wilson LOW, Bauer DC, Perrin D.   +7 more
europepmc   +1 more source

Accelerating Hyperparameter Tuning in Machine Learning for Alzheimer's Disease With High Performance Computing. [PDF]

Front Artif Intell, 2021
Zhang F, Petersen M, Johnson L, Hall J, O'Bryant SE.   +4 more
europepmc   +1 more source

PT-ESM: A Parameter-Testing and Integration Framework for Earth System Models Oriented towards High-Performance Computing [PDF]

Jiaxu Guo, Liang Hu, Gaochao Xu, Juncheng Hu, Xilong Che   +4 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Ten simple rules for building and maintaining sustainable high-performance computing infrastructure for research in resource-limited settings. [PDF]

PLoS Comput Biol
Galiwango R, Whalen CJ, Kebirungi G, Atwine MT, Kimera R, Ssekagiri A, Kimbowa TW, Lukyamuzi E, Nsubuga M, eLwazi ODSP, Ssentongo L, Mutegeki H, Fonner JM, Wuerthwein F, Berman A, Okalebo LB, McCarthy M, Kramer VS, Quinones M, Cruz P, Hurt D, Giovanni MY, Mulder N, Tartakovsky M, Kayondo J, Jjingo D.   +25 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Scale-up Unlearnable Examples Learning with High-Performance Computing. [PDF]

IS&T Int Symp Electron Imaging
Zhu Y, Lyngaas I, Gopalakrishnan Meena M, Koran MEI, Malin B, Moyer D, Bao S, Kapadia A, Wang X, Landman B, Huo Y.   +10 more
europepmc   +1 more source

Perspective of drug design with high-performance computing. [PDF]

Natl Sci Rev, 2021
Li Z, Li H, Yu K, Luo HB.
europepmc   +1 more source

Towards industrial-scale bubble columns: the development and application of the high performance computing framework

, 2019
M.V. Masterov
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source