Results 111 to 120 of about 6,298,750 (294)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A High permormance hardware architecture for an sad reuse based hierarchical motion estimation algorithm for H.264 video coding [PDF]

, 2005
In this paper, we present a high performance and low cost hardware architecture for real-time implementation of an SAD reuse based hierarchical motion estimation algorithm for H.264 / MPEG4 Part 10 video coding.
Ates, Hasan F., Ateş, Hasan F., Hamzaoglu, Ilker, Hamzaoğlu, İlker, Yalcin, Sinan, Yalçın, Sinan   +5 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The HPCG benchmark: analysis, shared memory preliminary improvements and evaluation on an Arm-based platform [PDF]

, 2018
The High-Performance Conjugate Gradient (HPCG) benchmark complements the LINPACK benchmark in the performance evaluation coverage of large High-Performance Computing (HPC) systems. Due to its lower arithmetic intensity and higher memory pressure, HPCG is
Casas, Marc, Labarta Mancho, Jesús José, Mantovani, Filippo, Ruiz, Daniel, Spiga, Filippo   +4 more
core   +1 more source

An Integrated System at the Bleien Observatory for Mapping the Galaxy

, 2016
We describe the design and performance of the hardware system at the Bleien Observatory. The system is designed to deliver a map of the Galaxy for studying the foreground contamination of low-redshift (z=0.13--0.43) H$_{\rm I}$ intensity mapping ...
Akeret, Joel, Amara, Adam, Chang, Chihway, Glauser, Adrian, Monstein, Christian, Refregier, Alexandre, Seehars, Sebastian, Stuber, Bruno   +7 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

An empirical investigation on the relationship between a high-performance work system and employee performance: measuring a mediation model through partial least squares–structural equation modeling

Psychology Research and Behavior Management, 2019
Cai Li, Shumaila Naz, Muhammad Aamir Shafique Khan, Basil Kusi, Majid MuradSchool of Management, Jiangsu University, Zhenjiang, Jiangsu 212013, People’s Republic of ChinaBackground: This study aimed to investigate the effect of a high-performance ...
Li C, Naz S, Khan MAS, Kusi B, Murad M
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