Results 91 to 100 of about 2,007,040 (267)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Deep learning-based aberration compensation improves contrast and resolution in fluorescence microscopy

Nature Communications
Optical aberrations hinder fluorescence microscopy of thick samples, reducing image signal, contrast, and resolution. Here we introduce a deep learning-based strategy for aberration compensation, improving image quality without slowing image acquisition,
Min Guo, Yicong Wu, Chad M. Hobson, Yijun Su, Shuhao Qian, Eric Krueger, Ryan Christensen, Grant Kroeschell, Johnny Bui, Matthew Chaw, Lixia Zhang, Jiamin Liu, Xuekai Hou, Xiaofei Han, Zhiye Lu, Xuefei Ma, Alexander Zhovmer, Christian Combs, Mark Moyle, Eviatar Yemini, Huafeng Liu, Zhiyi Liu, Alexandre Benedetto, Patrick La Riviere, Daniel Colón-Ramos, Hari Shroff   +25 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

[N i] 10400/10410 Å Lines as Possible Disk Wind Tracers in a Young Intermediate-mass Star

The Astrophysical Journal
In this study, we performed high-resolution near-infrared (NIR) spectroscopy ( R = 28,000; λ = 0.90–1.35 μ m) with a high signal-to-noise ratio on HD 200775, a very young (∼0.1 Myr old) and massive intermediate-mass star (a binary star with a mass of ...
Haruki Katoh, Chikako Yasui, Yuji Ikeda, Naoto Kobayashi, Noriyuki Matsunaga, Sohei Kondo, Hiroaki Sameshima, Satoshi Hamano, Misaki Mizumoto, Hideyo Kawakita, Kei Fukue, Shogo Otsubo, Keiichi Takenaka   +12 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Post-Irradiation Annealing of Bi Ion Tracks in Si₃N₄: In-Situ and Ex-Situ Transmission Electron Microscopy Study

Crystals
High-energy (710 MeV) Bi ion track morphology in polycrystalline silicon nitride was investigated during post-irradiation annealing. Using both in-situ and ex-situ transmission electron microscopy, we monitored the recovery of crystallinity within ...
Anel Ibrayeva, Jacques O’Connell, Ruslan Rymzhanov, Arno Janse van Vuuren, Vladimir Skuratov   +4 more
doaj   +1 more source