Results 71 to 80 of about 2,007,040 (267)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

In situ electron diffraction tomography study of the successive phase transitions in LaTaO4 nanocrystals

Nature Communications
The ferroelectric oxide LaTaO4, with a layered perovskite-related structure, exhibits a reversible temperature-dependent phase transition between its low-temperature paraelectric and high-temperature ferroelectric states.
Shitao Wu, Changhan Peng, Wuzong Zhou, Finlay D. Morrison, Grant W. Howieson, Yanhang Ma   +5 more
doaj   +1 more source

Untwisting the Caenorhabditis elegans embryo

eLife, 2015
The nematode Caenorhabditis elegans possesses a simple embryonic nervous system with few enough neurons that the growth of each cell could be followed to provide a systems-level view of development.
Ryan Patrick Christensen, Alexandra Bokinsky, Anthony Santella, Yicong Wu, Javier Marquina-Solis, Min Guo, Ismar Kovacevic, Abhishek Kumar, Peter W Winter, Nicole Tashakkori, Evan McCreedy, Huafeng Liu, Matthew McAuliffe, William Mohler, Daniel A Colón-Ramos, Zhirong Bao, Hari Shroff   +16 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Allosteric coupling between G‐protein binding and extracellular ligand binding sites in GPR52 revealed by 19F‐NMR and cryo‐electron microscopy

MedComm, 2023
Yanliu Fan, Xi Lin, Benxun Pan, Bo Chen, Dongsheng Liu, Kurt Wüthrich, Fei Xu   +6 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

High resolution electrocardiography.

Indian pacing and electrophysiology journal, 2002
Over the past decade, significant advances were made in the research, diagnosis, and treatment of cardiovascular diseases. Such progress was in every sphere of cardiology that includes non-invasive, minimally invasive, and invasive technologies. Interpretive electrocardiography, cardiac pacemakers, cardiac stents, and angioplasty are some areas where ...
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

AutoLEI: A step towards automatic 3D ED data processing

IUCrJ
A user-friendly interface has been developed for XDS, enabling efficient real-time and batch processing of 3D ED data to accelerate structure determination.
Shitao Wu, Yanhang Ma
doaj   +1 more source