Results 111 to 120 of about 852,877 (303)
A multiscale modelling framework of coastal flooding events for global to local flood hazard assessments [PDF]
Natural Hazards and Earth System SciencesTropical and extratropical cyclones, which can cause coastal flooding, are among the most devastating natural hazards. Understanding coastal flood risk better can help to reduce their potential impacts. Global flood models play a key role in this process.
I. Benito +8 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Insights into the terminal pleistocene climate of Australia from high resolution climate modelling
Scientific ReportsInterpretations of the palaeoclimate at the end of the deglaciation over Australia suggest that conditions were becoming warmer, but there is an inconsistent picture of the monsoon and its impacts.
Andrew L. Lowry, Hamish A. McGowan
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Use of multi-angle high-resolution imagery and 3D information for urban land-cover classification: a case study on Istanbul [PDF]
, 2010 The BELSPO-MAMUD project focuses on the use of Remote Sensing data for measuring and modelling urban dynamics. Remote sensing is a wonderful tool to produce long time-series of high resolution maps of sealed surface useful for this purpose.
Binard, Marc +4 more
core +1 more source
Downscaling and global high-resolution modelling
, 2022 Talk at Hectometric Workshop at ...
openaire +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Modelling the disk atmosphere of the low mass X-ray binary EXO 0748-676
, 2018 Low mass X-ray binaries exhibit ionized emission from an extended disk atmosphere that surrounds the accretion disk. However, its nature and geometry is still unclear. In this work we present a spectral analysis of the extended atmosphere of EXO 0748-676
Costantini, Elisa +3 more
core +1 more source