Results 121 to 130 of about 852,877 (303)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Heliospheric modulation of the interstellar dust flow on to Earth
, 2018 Aims. Based on measurements by the Ulysses spacecraft and high-resolution modelling of the motion of interstellar dust (ISD) through the heliosphere we predict the ISD flow in the inner planetary system and on to the Earth.
Grün, Eberhard +5 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
High resolution modelling of snow transport in complex terrain using downscaled MM5 wind fields [PDF]
The Cryosphere, 2010 Snow transport is one of the most dominant processes influencing the snow cover accumulation and ablation in high mountain environments. Hence, the spatial and temporal variability of the snow cover is significantly modified with respective consequences ...
M. Bernhardt +4 more
doaj
2D radiative modelling of He I spectral lines formed in solar prominences
, 2007 We present preliminary results of 2D radiative modelling of He I lines in solar prominences, using a new numerical code developed by us (Leger, Chevallier and Paletou 2007).
Leger, L., Paletou, F.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Connecting Physical and Socio‐Economic Spaces for Multi‐Scale Urban Modelling: A Dataset for London
Geoscience Data JournalVersatile approaches for urban modelling need to simultaneously consider the physical characteristics of a city (urban form) and urban function as a manifestation of economically, socially, and culturally motivated human activities.
Denise Hertwig +7 more
doaj +1 more source
High-resolution numerical modelling reveals tsunami risk hotspots in Xiamen City, China
Frontiers in Marine ScienceTsunamis, generated by submarine earthquakes, landslides, or volcanic eruptions, are a significant hazard to coastal areas owing to their sudden onset and rapid propagation speed.
Xianwu Shi +9 more
doaj +1 more source
Impact and spreading of microdrops on homo- and heterogeneous solids: Modelling and benchmark simulations [PDF]
, 2011 This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011) +2 more
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source