Results 131 to 140 of about 1,540,429 (310)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
About the seismic effects in the collapse of high-rise buildings [PDF]
, 2014 Наведені результати сейсмометричних вимірювань параметрів коливань земної поверхні при обваленні димової труби підривним способом і порівняння їх з наявними розрахунковими методами визначення сейсмічного ефекту при вказаному технологічному процесі.The ...
Boiko, V. V. +5 more
core
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Sustainable refurbishment solutions for high-rise residential buildings in subtropical areas [PDF]
, 2014 Conference Theme: Mass Customisation and Sustainability in HousingBuilding maintenance and refurbishment has become a particular concern in developed economies, as there are many old buildings in urban areas. While various refurbishment methods have been
Li, J, Lomas, K, Ng, TST, Zou, W
core
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Seismic response analysis of super-high-rise building structures with three-layer isolation systems. [PDF]
Sci Rep, 2023 Zhang Y, Guo Z, Liu D, Sun W.
europepmc +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Simulation and Optimization Study on the Ventilation Performance of High-Rise Buildings Inspired by the White Termite Mound Chamber Structure. [PDF]
Biomimetics (Basel), 2023 Wei Y, Lin Z, Wang Y, Wang X.
europepmc +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source