Results 141 to 150 of about 22,076,180 (336)

Wind environmental evaluation of neighborhood areas in major towns of Malaysia [PDF]

open access: yes, 2006
This paper discusses planning guidelines of neighborhood residential areas in consideration of wind flow in Malaysia. It aims to reduce the energy consumption particularly from the use of air-conditioners.
Ahmad, Supian, Kubota, Tetsu
core  

Safety Climate in High-Rise Construction

open access: yesBuildings
This study examines safety climate perceptions in construction using two models: the Safety Climate Model (SCM) and the Nordic Safety Climate Questionnaire (NOSACQ-50).
Igal M. Shohet, Roi Naveh, Fadi Shahin
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

UAV Air-to-Ground Channel Characterization for mmWave Systems

open access: yes, 2017
Communication at mmWave bands carries critical importance for 5G wireless networks. In this paper, we study the characterization of mmWave air-to-ground (AG) channels for unmanned aerial vehicle (UAV) communications.
Guvenc, Ismail   +2 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Surrounding buildings and wind pressure distribution on a high-rise building [PDF]

open access: yes, 2008
The effect of the surrounding lower buildings on the wind pressure distribution on a high-rise building is investigated by computational fluid dynamics (CFD). When B/H=0.1, it is found that the wind pressure on the windward side was reduced especially on
Luo, Zhiwen
core  

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

The Application of Green Design in the Interior Room in Terms of Material Selection [PDF]

open access: yes, 2019
Design with the Green Design approach is now starting to get more attention in interior planning in big cities in Indonesia. Human awareness about the environment and healthy living space is a driving factor.
Sudarisman, I. (Irwan )
core  

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