Results 151 to 160 of about 36,236,534 (364)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

HIGH-SPEED RAIL IN THE MIDWEST UNITED STATES: POTENTIAL FOR SUCCESS [PDF]

open access: yes
This paper assesses the potential for successful provision of high-speed rail (HSR) in the Midwestern United States, and concludes by identifying major lessons that other states and regions in the United States interested in developing HSR can draw from ...
Shishir MATHUR, Srikalyani SRINIVASAN
core  

Application of hydrogen marine systems in high-speed sea container transport [PDF]

open access: yes, 2007
Conventional marine fuels have always limited the endurance of high-speed ships leading to fast but inefficient cargo ships. This research considers the fuel weight barrier in high-speed ship design and the use of hydrogen as a marine fuel to overcome ...
Veldhuis, Ivo
core  

Simulation on Buffet Response and Mitigation of Variant-Tailed Aircraft in Maneuver State

open access: yesVibration
This study proposes a computational fluid dynamics and computational structure dynamics (CFD/CSD) coupled method for calculating the buffet response of a variant tail wing.
Dawei Liu   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Evaluation of balance measurement uncertainty based on standard error of calibration coefficients

open access: yesKongqi donglixue xuebao
The measurement uncertainty of strain gauge balance is one of the important sources of uncertainty in aircraft wind tunnel test data. The conventional methodology obtains the balance calibration formula through the comprehensive loading residual method ...
Chao Wang   +4 more
doaj   +1 more source

Machine Learning for High-Speed Corner Detection

open access: yesEuropean Conference on Computer Vision, 2006
E. Rosten, T. Drummond
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Florida High Speed Rail Authority - 2002 report to the legislature [PDF]

open access: yes
This report addresses a legislative requirement that the Authority issue a report of its actions, findings and recommendations. Previous high speed ground transportation studies were reviewed as part of the preparation of this report.
HNTB Corporation
core  

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