Results 51 to 60 of about 1,986,994 (260)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
High speed interferometric ellipsometer
Optics Express, 2008 A novel high speed interferometric ellipsometer (HSIE) is proposed and demonstrated. It is based on a novel differential-phase decoder which is able to convert the phase modulation into amplitude modulation in a polarized heterodyne interferometer.
Tsai, C. C. +5 more
openaire +3 more sources
High speed fluttering skids with elastic suspensions [PDF]
, 2012 In a recent project, named SEALAB, a novel marine vehicle has been developed. Its main characteristic is the presence of special skid surfaces surfing over rough water.
CARCATERRA, Antonio, PEPE, GIANLUCA
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Transition to High-Speed Networks — SuperJANET Experience [PDF]
, 1995 For the time being, trials to establish the Information Superhighway are booming. In Britain, JANET has provided wide-area computer communication, and has recently been upgraded to SuperJANET, increasing the throughput by a factor of five to 10 Mb/s ...
Hutchison, David +3 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Flexible high speed codec [PDF]
The project's objective is to develop an advanced high speed coding technology that provides substantial coding gains with limited bandwidth expansion for several common modulation types.
Boyd, R. W., Hartman, W. F.
core +1 more source
Superconducting ''transistor'' acts as high-speed switch [PDF]
, 1970 Cryogenic, three-terminal device yields current-voltage characteristics of ordinary transistor. Device consists of two superconducting tin rods in a crossed-wire geometry, separated by a thin gold film.
Meissner, H.
core +1 more source
Research Towards High Speed Freeforming [PDF]
, 2013 Additive manufacturing (AM) methods are currently utilised for the manufacture of prototypes and low volume, high cost parts. This is because in most cases the high material costs and low volumetric deposition rates of AM parts result in higher per part ...
Brooks, Hadley Laurence +2 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source