Results 101 to 110 of about 1,688,919 (301)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Актуальные международно-правовые аспекты противодействия преступлениям, совершаемым в сфере высоких технологий [PDF]
, 2017 ACTUAL INTERNATIONAL LEGAL ISSUES COUNTERACTION AGAINST CRIMINALS PERFORMED IN THE SPHERE OF HIGH TECHNOLOGIES P. BOROVIKРассматриваются проблемные вопросы международного противодействия преступлениям, совершаемым в сфере высоких технологий.
Боровик, П. Л.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Кардиоваскулярная терапия и профилактика, 2007 Aim. To study clinical equivalence of two bisoprolol medications (Concor ® and Bisogamma®) in patients with mild to moderate arterial hypertension (AH). Material and methods. The study included 32 AH patients (15 men, 17 women): 66 % with Stage I, and 34
S. Yu. Martsevich +8 more
doaj
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Carbon dot dressing as a treatment of alkali-induced skin burns
Біологічні студіїBackground. Chemical burns, comprising 5–10 % of total burns but causing 30 % of burn-related deaths, are now a notable concern in Ukraine. Current clinical protocols lack specific approaches for chemical burns, and research on this type of burn is ...
Halyna Kuznietsova +11 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Towards atomic-resolution electron energy loss spectroscopy in an uncorrected 30kV scanning electron microscope [PDF]
BIO Web of ConferencesRamasse Quentin +10 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Eastern Enlargement of the EU: Bulgaria and Romania’s Accession- Geo-economic and Geopolitical Implications for the Balkans [PDF]
The project’s aim is to look beyond the journalistic flash stories and the repetitive high pathos analysis of EU's Balkan Enlargement and explore in depth the geopolitical implications of such an important development.
Klimov, Blagoy
core +1 more source