Results 121 to 130 of about 21,494,841 (260)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2017 Toledo Central High School was bounded by Madison, Michigan, Adams and 10th Streets. Toledo Central High School occupied this location from approximately 1898-1914. Later, this would become the site of the Toledo Lucas County Public Library. An alternate
Toledo Central High School (Toledo, Ohio)
core
Prevalence of total cardiovascular risk components among primary healthcare workers
Кардиоваскулярная терапия и профилактика, 2009 Aim. To study the prevalence of total cardiovascular (CV) risk components among medical professionals working in primary healthcare.Material and methods.
N. S. Karamnova +4 more
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Кардиоваскулярная терапия и профилактика, 2009 Aim. То evaluate clinical effectiveness of eprosartan and hydroxyzine in patients with mild to moderate arterial hypertension (AH) and coexisting anxiety.Material and methods. The study included 34 patients (8 men, 26 women) aged 36—76 years (mean age 56,
G. V. Pogosova +4 more
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Кардиоваскулярная терапия и профилактика, 2008 Aim. To investigate effectiveness and safety of ramipril therapy, with varying administration time, in patients with mild to moderate arterial hypertension (AH) and overweight (OW).Material and methods. The patients were randomized into two groups: Group
I. P. Kolos +4 more
doaj
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source