Results 11 to 20 of about 2,820 (61)

Improving the Thermostability of Serine Protease PB92 from Bacillus alcalophilus via Site-Directed Mutagenesis Based on Semi-Rational Design

Foods, 2023
Proteases have been widely employed in many industrial processes. In this work, we aimed to improve the thermostability of the serine protease PB92 from Bacillus alcalophilus to meet the high-temperature requirements of biotechnological treatments. Eight
Huabiao Miao, Xia Xiang, Nanyu Han, Qian Wu, Zunxi Huang   +4 more
semanticscholar   +1 more source

High Temperature Requirement A3 (HtrA3) Promotes Etoposide- and Cisplatin-induced Cytotoxicity in Lung Cancer Cell Lines*

Journal of Biological Chemistry, 2010
Lung cancer is the leading cause of cancer-related deaths worldwide. Here we show for the first time that HtrA3 is a mitochondrial stress-response factor that promotes cytotoxicity to etoposide and cisplatin in lung cancer cell lines.
Daniah T Beleford, R. Rattan, J. Chien, V. Shridhar   +3 more
semanticscholar   +1 more source

High temperature requirement A1 and macrophage migration inhibitory factor in the cerebrospinal fluid; a potential marker of conversion from relapsing-remitting to secondary progressive multiple sclerosis.

Journal of Neurological Sciences
BACKGROUND Predictive and prognostic biomarkers for multiple sclerosis (MS) remain a significant gap in MS diagnosis and treatment monitoring.
Simone Hjæresen, E. Benedikz, T. Sejbaek, M. Axelsson, L. Novakova, Mengliang Zhang, J. Lycke, Z. Illés, Åsa Fex-Svenningsen   +8 more
semanticscholar   +1 more source

Role of Fe addition in Ni–Mn–Ga–Co–Cu–Fe ferromagnetic shape memory alloys for high-temperature magnetic actuation

, 2020
The Ni–Mn–Ga ferromagnetic shape memory alloys (FSMAs) are a group of active materials that undergo martensitic transformations (MTs) induced by temperature, stress and/or magnetic fields, resulting in large recoverable mechanical deformations.
A. Pérez-Checa, J. Porro, J. Feuchtwanger, P. Lázpita, T. Hansen, C. Mondelli, A. Sozinov, J. Barandiaran, K. Ullakko, V. Chernenko   +9 more
semanticscholar   +1 more source

Phase 2 Study of the Anti-High Temperature Requirement A1 (HtrA1) Fab Galegenimab (FHTR2163) in Geographic Atrophy Secondary to Age-Related Macular Degeneration.

American journal of ophthalmology-glaucoma
PURPOSE To investigate the safety, tolerability, and efficacy of intravitreal injection of galegenimab, an anti-HtrA1 FAb, in patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD).
D. Eichenbaum, Nancy M Holekamp, A. Khanani, D. Pieramici, Vrinda S. Hershberger, Veeral S. Sheth, Flavia Brunstein, Ling Ma, Yixuan Zou, Vahan B. Indjeian, Randall Dere, Mauricio Maia, Joy C. Hsu, Simon S. Gao, B. Yaspan, Jeffrey R. Willis, Henry Wiley, Phillip Lai, Hao Chen   +18 more
semanticscholar   +1 more source

ASSESSMENT OF SOLAR PV POWER POTENTIAL IN THE ASIA PACIFIC REGION WITH REMOTE SENSING CONSIDERING THE EFFECTS OF HIGH TEMPERATURE, DUST AND SNOW

, 2019
. The last half century has witnessed the increasing trend of renewable energy utilization with solar photovoltaic (PV) systems as one of the most popular option.
J. Principe, W. Takeuchi
semanticscholar   +1 more source

Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA

Gut Pathogens, 2019
Campylobacter jejuni secretes HtrA (high temperature requirement protein A), a serine protease that is involved in virulence. Here, we investigated the interaction of HtrA with the host protein occludin, a tight junction strand component ...
A. Harrer, R. Bücker, M. Boehm, Urszula Zarzecka, Nicole Tegtmeyer, H. Sticht, J. Schulzke, S. Backert   +7 more
semanticscholar   +1 more source

Phytase as an alleviator of high‐temperature stress in broilers fed adequate and low dietary calcium

Poultry Science, 2019
This study aimed to investigate the effect of phytase and dietary Ca level on performance, phytate (inositol hexa‐phosphate, IP6) concentration, and anti‐oxidant enzyme activity in broilers exposed to cycling high environmental temperatures. A total of 2,
Sophie A. Lee, D. Nagalakshmi, M. Raju, S. V. R. Rao, M. Bedford, C. Walk   +5 more
semanticscholar   +1 more source

Redox and solvent-stable alkaline serine protease from Bacillus patagoniensis DB-5: heterologous expression, properties, and biotechnological applications

Frontiers in Microbiology
The aprBP gene from Bacillus patagoniensis DB-5, encoding a 378-amino-acid alkaline protease, was cloned and expressed in Escherichia coli. The amino acid sequence of APrBP showed 62.8–84.4% identity with the S8 peptidase subtilisin family alkaline ...
Zhimin Li, Yanmin Xing, Pulin Liu, Weifang Liao, Lihong Miao   +4 more
semanticscholar   +1 more source

Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment

Communications Biology, 2019
Osteoclasts are multinucleated cells responsible for bone resorption. The differentiation of osteoclasts from bone marrow macrophages (BMMs) is induced by receptor activator of NF-κB ligand (RANKL).
Nagahiro Ochiai, Yutaka Nakachi, Tomotaka Yokoo, T. Ichihara, Tore Eriksson, Yuki Yonemoto, Takehiko Kato, Hitoshi Ogata, Natsuko Fujimoto, Yasuhiro Kobayashi, N. Udagawa, S. Kaku, T. Ueki, Y. Okazaki, N. Takahashi, T. Suda   +15 more
semanticscholar   +1 more source