Results 241 to 250 of about 61,294 (275)

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, EarlyView.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source

scSNV-seq: high-throughput phenotyping of single nucleotide variants by coupled single-cell genotyping and transcriptomics. [PDF]

Genome Biol
Cooper SE, Coelho MA, Strauss ME, Gontarczyk AM, Wu Q, Garnett MJ, Marioni JC, Bassett AR.   +7 more
europepmc   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

High throughput phenotyping... What’s going on

, 2013
openaire   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

High-throughput mouse phenotyping

Methods, 2011
Comprehensive phenotyping will be required to reveal the pleiotropic functions of a gene and to uncover the wider role of genetic loci within diverse biological systems. The challenge will be to devise phenotyping approaches to characterise the thousands of mutants that are being generated as part of international efforts to acquire a mutant for every ...
Muller, Werner, Gates, Hilary, Mallon, Ann Marie, Brown, Steve D M   +3 more
openaire   +5 more sources

High-Throughput Phenotyping in Soybean

2021
Soybean [Glycine max (L.) Merr.] breeders and geneticists routinely evaluate thousands of plots per year in order to characterize various accessions and breeding populations for a multitude of traits, for example, morphological, physiological, abiotic and biotic stress, plant organs, and seed composition.
Asheesh K. Singh, Arti Singh, Soumik Sarkar, Baskar Ganapathysubramanian, William Schapaugh, Fernando E. Miguez, Clayton N. Carley, Matthew E. Carroll, Mariana V. Chiozza, Kevin O. Chiteri, Kevin G. Falk, Sarah E. Jones, Talukder Z. Jubery, Seyed V. Mirnezami, Koushik Nagasubramanian, Kyle A. Parmley, Ashlyn M. Rairdin, Johnathon M. Shook, Liza Van der Laan, Therin J. Young, Jiaoping Zhang   +20 more
openaire   +1 more source

High-throughput phenotyping

Nature Methods, 2009
Automated methods to score phenotypes in model organisms continue to develop and will permit previously inaccessible areas of biology to be probed.
openaire   +1 more source

High-Throughput Phenotypic Profiling

2021
Presentation to the U.S. EPA ORD, CSS Research Program Board of Scientific Counselors (BOSC) Chemical Safety Subcommittee Meeting February ...
openaire   +1 more source

High-Throughput Phenotyping of Plant Shoots

2012
Advances in automated plant handling and image acquisition now make it possible to use digital imaging for the high-throughput phenotyping of plants. Various traits can be extracted from individual images. However, the potential of this technology lies in the acquisition of time series.
Berger, B., de Regt, S., Tester, M.
openaire   +3 more sources