Results 271 to 280 of about 615,917 (326)

Deep learning-based elaiosome detection in milk thistle seed for efficient high-throughput phenotyping. [PDF]

Front Plant Sci
Kim Y, Abebe AM, Kim J, Hong S, An K, Shim J, Baek J.   +6 more
europepmc   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Estimation of soybean yield based on high-throughput phenotyping and machine learning. [PDF]

Front Plant Sci
Li X, Chen M, He S, Xu X, He L, Wang L, Gao Y, Tang F, Gong T, Wang W, Xu M, Liu C, Yu L, Liu W, Yang W.   +14 more
europepmc   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Editorial: Enriching genomic breeding with environmental covariates, crop models, and high-throughput phenotyping. [PDF]

Front Genet
Xavier A, Rainey KM, Robbins KR.
europepmc   +1 more source

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

Editorial: Increasing sustainability in livestock production systems through high-throughput phenotyping approaches. [PDF]

Front Genet
Maiorano AM, Ablondi M, Qiao Y, Steibel JP, Bernal Rubio YL.   +4 more
europepmc   +1 more source

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

High-throughput phenotyping using hyperspectral indicators supports the genetic dissection of yield in durum wheat grown under heat and drought stress. [PDF]

Front Plant Sci
Mérida-García R, Gálvez S, Solís I, Martínez-Moreno F, Camino C, Soriano JM, Sansaloni C, Ammar K, Bentley AR, Gonzalez-Dugo V, Zarco-Tejada PJ, Hernandez P.   +11 more
europepmc   +1 more source

Implementation of theoretical non-photochemical quenching (NPQ_(T)) to investigate NPQ of chickpea under drought stress with High-throughput Phenotyping. [PDF]

Sci Rep
Lauterberg M, Tschiersch H, Zhao Y, Kuhlmann M, Mücke I, Papa R, Bitocchi E, Neumann K.   +7 more
europepmc   +1 more source