Results 131 to 140 of about 1,074,205 (395)

SEED 2: a user-friendly platform for amplicon high-throughput sequencing data analyses

Bioinform., 2018
Motivation Modern molecular methods have increased our ability to describe microbial communities. Along with the advances brought by new sequencing technologies, we now require intensive computational resources to make sense of the large numbers of ...
T. Větrovský, P. Baldrian, Daniel C. Morais   +2 more
semanticscholar   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Metagenomic Sequencing of Maize Reveals Abundant Genomic RNA of a Comovirus, a Genus Previously Known to Infect Only Dicots [PDF]

The Plant Pathology Journal
To better understand the diversity of viral pathogens in Türkiye, a major exporter of cereals in Europe, we performed high-throughput sequencing of total RNA from maize plants collected in the Trakya region.
Havva Ilbağı, Surapathrudu Kanakala, Rick Masonbrink, Zachary Lozier, W. Allen Miller   +4 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Use of high throughput sequencing to observe genome dynamics at a single cell level

, 2009
With the development of high throughput sequencing technology, it becomes possible to directly analyze mutation distribution in a genome-wide fashion, dissociating mutation rate measurements from the traditional underlying assumptions. Here, we sequenced
A. Soldatov, Bentley, Benzer, Bhanot, Cai, Cairns, Cox, Cupples, D. Parkhomchuk, Dotsch, Elowitz, Foster, Foster, Gabriel, Goodarzi, Hall, Hill-Perkins, Lindahl, Loechler, Loveless, Meselson, Mitra, Niki, Raser, Rosche, Sedgwick, Singer, V. Amstislavskiy, V. Ogryzko, Yu   +29 more
core   +1 more source

A Reference Viral Database (RVDB) To Enhance Bioinformatics Analysis of High-Throughput Sequencing for Novel Virus Detection

Msphere, 2018
To facilitate bioinformatics analysis of high-throughput sequencing (HTS) data for the detection of both known and novel viruses, we have developed a new reference viral database (RVDB) that provides a broad representation of different virus species from
Norman Goodacre, Aisha AlJanahi, S. Nandakumar, Mike Mikailov, Arifa S. Khan   +4 more
semanticscholar   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

V-pipe: a computational pipeline for assessing viral genetic diversity from high-throughput sequencing data [PDF]

, 2020
Susana Posada-Céspedes, David Seifert, Ivan Topolsky, Karin J. Metzner, Niko Beerenwinkel   +4 more
openalex   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

TrieDedup: A fast trie-based deduplication algorithm to handle ambiguous bases in high-throughput sequencing [PDF]

, 2022
Jianqiao Hu, Sai Luo, Ming Tian, Adam Yongxin Ye   +3 more
openalex   +1 more source