Results 221 to 230 of about 3,603,990 (303)

Acceptability of 100-mg moxifloxacin in children with rifampicin-resistant TB in three high-burden countries. [PDF]

IJTLD Open
Suryavanshi N, Draper HR, Dhumal G, Bagchi S, Castillo-Carandang NT, Marthinus A, Cheong AMA, Kinikar A, Paradkar M, Gupta A, Ocampo JDR, Frias MVG, Casalme DJO, Hesseling A, Garcia-Prats AJ, Palmer M, Hoddinott G, Viljoen L, CATALYST Trial Team.   +18 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Congenital tuberculosis in preterm infants in a high-burden setting in southwest China: a single-center cross-sectional study. [PDF]

Front Pediatr
Zhuang X, Xu W, Xu W, Shi Y, Xiao M, Rihei A, Dong W, Bian C.   +7 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Start4All protocol for a Bayesian cost-effectiveness model of tuberculosis screening and diagnosis in seven high burden low-income and middle-income countries. [PDF]

BMJ Open
McCoy A, Garg T, Henrion M, Vo LNQ, Wingfield T, Worrall E, Start4All: Start Taking Action for TB Diagnosis investigators.   +6 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

The synergy of therapeutic vaccination and timely diagnosis for TB control in high-burden settings: Nunavut as a case study. [PDF]

J Clin Tuberc Other Mycobact Dis
Abdollahi E, Moghadas SM, Galvani AP.
europepmc   +1 more source