Results 61 to 70 of about 922,426 (306)

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Design Method of High Speed Ratio Planetary Gear Transmission（NGWN（Ⅱ））Considering Efficiency and Dynamics Performance

Jixie chuandong, 2018
Aiming at the problem of the low efficiency of NGWN-type planetary gear transmission with high speed ratio,the low-loss gear design that is optimizing modification coefficients and addendum coefficients simultaneously,reducing the contact ratio to reduce
Wang Jianxiang, Qin Datong
doaj  

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Sealing and zero leakage characteristics of a high-pressure large-sized main drive based on active pressure compensation

工程科学学报
The main drive system of a shaft full-section tunnel boring machine (TBM) may face the impact of a high-pressure mud load caused by sudden water gushing, which imposes strict requirements on the reliability of the system seal.
Lifang ZHENG, Chao FANG, Fei MA, Tengfei CAI, Man YAO   +4 more
doaj   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Knee adduction moment and medial contact force - facts about their correlation during gait

, 2013
The external knee adduction moment is considered a surrogate measure for the medial tibiofemoral contact force and is commonly used to quantify the load reducing effect of orthopedic interventions. However, only limited and controversial data exist about
Bergmann, Georg, Georg Bergmann, Adam Trepczynski, Markus O Heller, Kutzner, Ines, Trepczynski, Adam, Heller, Markus O., Ines Kutzner   +7 more
core   +1 more source

Comparison of PVD Coatings Nacro4 and TIALN + DLC Deposited on High Contact Ratio Gearing Interacting With Conventional and Ecological Lubricants

Acta Technologica Agriculturae, 2019
Proposed paper deals with experimental tests performed on the Nieman M01 FZG test rig. Experiments were carried out in accordance with STN 65 6280 standard for FZG scuffing tests, from which load values for each load level were obtained.
Fürstenzeller Adam, Tóth František, Kadnár Milan, Rusnák Juraj, Bošanský Miroslav   +4 more
doaj   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Spherical gearing with intermediate ball elements: parameter ranges with a high contact ratio

, 2020
The paper presents analytical research of the geometry and kinematical parameters of spherical gearing with ball intermediate elements. The main attention is paid to the influence of the offset coefficient on the tooth geometry generation, the contact ...
Gorbenko, T. I., Gorbenko, M. V.
core   +2 more sources