Results 41 to 50 of about 922,426 (306)

The unusual, high-mass-ratio contact binary VZ PISCIUM

The Astronomical Journal, 1989
Radial-velocity curves have been determined for the short-period W UMa type binary VZ Psc using the cross-correlation method. These yield a mass ratio of 0.92 + or - 0.03, a value closer to unity than that reported for any other W UMa binary thus far. Strong Ca II H and K emission is associated with each component.
Bruce J. Hrivnak, E. F. Milone
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A modified particle contact model for matching the ratios of uniaxial compressive to tensile strength of brittle rocks

Geomechanics and Geophysics for Geo-Energy and Geo-Resources, 2023
The Hertz-Mindlin with bonding (HMB) contact model in the commercial discrete element method (DEM) software EDEM is widely used to simulate and analyze the mechanical behavior of rocks.
Yan Wu, Haichun Hao, Mingzhong Gao, Zheng Gao, Yanan Gao   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Geometry and parameter design of novel circular arc helical gears for parallel-axis transmission

Advances in Mechanical Engineering, 2017
Based on the space curve meshing equation, in this article, a geometry design of a novel circular arc helical gear mechanism with pure rolling for parallel transmission was presented.
Zhen Chen, Huafeng Ding, Bo Li, Linbo Luo, Liang Zhang, Jing Yang   +5 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Reduction of Vibration in Spur Gears by an Asymmetric Tooth Profile With High Contact Ratio

, 2017
Gear drive is a mechanism transmitting a power and a motion through the teeth contact. The number of teeth in contact changes during a mesh cycle. That raises a discontinuity of the mesh stiffness, and causes a gear vibration. The discontinuity implies a
Kiyotaka Ikejo, Kazuteru Nagamura, Ryo Fujikawa, Soichi Ibaraki   +3 more
core   +1 more source

Effects of surface defects on rolling contact fatigue of 60/40 brass [PDF]

, 1999
A study into effects of surface defects on rolling contact fatigue of 60/40 brass under a maximum contact pressure of 600 MPa and a slide–roll ratio of ?1% was undertaken on a twin-disc rolling–sliding test machine.
Beynon, J. H., Gao, N., Dwyer-Joyce, R. S.   +2 more
core   +1 more source