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High-Density Lipoproteins and the Kidney [PDF]
Cells, 2021 Dyslipidemia is a typical trait of patients with chronic kidney disease (CKD) and it is typically characterized by reduced high-density lipoprotein (HDL)-cholesterol(c) levels. The low HDL-c concentration is the only lipid alteration associated with the progression of renal disease in mild-to-moderate CKD patients.
Strazzella A., Ossoli A., Calabresi L.
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High Density Lipoproteins and Diabetes
Cells, 2021 Epidemiological studies have established that a high plasma high density lipoprotein cholesterol (HDL-C) level is associated with reduced cardiovascular risk. However, recent randomised clinical trials of interventions that increase HDL-C levels have failed to establish a causal basis for this relationship.
Cochran, BJ +3 more
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High-density lipoprotein is a nanoparticle, but not all nanoparticles are high-density lipoprotein [PDF]
Proceedings of the National Academy of Sciences, 2013 High-density lipoprotein (HDL) is a natural nanoparticle that transports cholesterol from peripheral tissues to the liver and also transports other lipids, proteins, enzymes, and microRNAs. HDL–cholesterol levels are negatively correlated with the risk of cardiovascular events.
Zahi A. Fayad +4 more
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Dysfunctional high-density lipoprotein [PDF]
Current Opinion in Endocrinology, Diabetes & Obesity, 2009 To address the progress of the investigation on dysfunctional high-density lipoprotein (HDL).HDL is generally considered to be an independent protective factor against cardiovascular disease. However, emerging evidence indicates that HDL can be modified under certain circumstances and lose its protective effect or even become atherogenic.
Xiang-An Li, Hong Feng
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High-Density Lipoproteins in Stroke [PDF]
, 2014 Besides their well-documented function of reverse transport of cholesterol, high-density lipoproteins (HDLs) display pleiotropic effects due to their antioxidant, antithrombotic, anti-inflammatory and antiapoptotic properties that may play a major protective role in acute stroke, in particular by limiting the deleterious effects of ischaemia on the ...
Olivier Meilhac, Olivier Meilhac
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Maturation of high-density lipoproteins
Journal of The Royal Society Interface, 2009 Human high-density lipoproteins (HDLs) are involved in the transport of cholesterol. The mechanism by which HDL assembles and functions is not well understood owing to a lack of structural information on circulating spherical HDL. Here, we report a series of molecular dynamics simulations that describe the maturation of discoidal HDL into spherical HDL
Stephen G. Sligar +2 more
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Assembly of High-Density Lipoprotein [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2006 Mammalian somatic cells do not catabolize cholesterol and need to export it for its homeostasis at the levels of cells and whole bodies. This reaction may reduce intracellularly accumulated cholesterol in excess and would contribute to prevention or regression of the initial stage of atherosclerosis.
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High-Density Lipoproteins [PDF]
Journal of the American College of Cardiology, 2012 The substantial residual cardiovascular events present in statin-treated patients provide a challenge to researchers in the cardiovascular field to develop additional therapeutic approaches. In cardiovascular disease (CVD) epidemiology, few associations are as consistent and enduring as the ...
Chunyu Zheng, Masanori Aikawa
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High density lipoproteins and exercise. [PDF]
British Journal of Sports Medicine, 1980 High density lipoprotein (HDL) and total cholesterol (TC) levels have been measured and their ratio compared in four groups of subjects - those with vascular disease, controls, middle-aged "keep-fit" enthusiasts and young physical education students. Each group has also been subjected to analysis of risk factors known for atherosclerosis. The HDL level
D. R. Donaldson, R. C. Kester
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High Density Lipoprotein and it's Dysfunction [PDF]
The Open Biochemistry Journal, 2012 Plasma high-density lipoprotein cholesterol(HDL-C) levels do not predict functionality and composition of high-density lipoprotein(HDL). Traditionally, keeping levels of low-density lipoprotein cholesterol(LDL-C) down and HDL-C up have been the goal of patients to prevent atherosclerosis that can lead to coronary vascular disease(CVD).
Esin Eren, Necat Yilmaz, Ozgur Aydin
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