Results 161 to 170 of about 1,615,493 (360)

Covalent Organic Frameworks‐Delivered Reuterin Drives Trained Immunity in Tumor‐Associated Macrophages to Enhance Melanoma Immunotherapy via Glycerophospholipid Metabolism

Advanced Science, EarlyView.
Covalent organic framework (COF)‐reuterin induces trained immunity in tumor‐associated macrophages, promoting the generation of nitric oxide and reactive oxygen species, thereby enhancing the antitumor immune response. Additionally, COF‐Reuterin directly kills tumor cells while simultaneously eradicating pathogenic intratumoural bacteria.
Jian‐Gang Zhang, Xiao‐Mei Zhang, Xi Wu, Cheng‐Kai Zhou, Zhen‐Zhen Liu, Xue‐Yue Luo, Liang Zhang, Wei Chen, Yong‐Jun Yang   +8 more
wiley   +1 more source

Deciphering the Acetabular Labrum's Cellular Atlas: MDK Inhibition as a Novel Therapeutic Method for Developmental Dysplasia of the Hip

Advanced Science, EarlyView.
This study explores developmental dysplasia of the hip (DDH) by analyzing acetabular labrum abnormalities using single‐cell and spatial transcriptomics. Aberrant fibrocartilage stem cell proliferation is linked to DDH progression. Targeting the MK signaling pathway with a specific inhibitor effectively alleviates early DDH abnormalities, offering ...
Runze Yang, Huiling Liu, Minghao Ge, Dingyuan Zhang, Tianhao Xu, Lei Zhang, Yanlin Zhu, Shun Li, Jian Li, Xin Ma, Weili Fu   +10 more
wiley   +1 more source

Dynamic properties of human high density lipoprotein apoproteins.

Journal of Lipid Research, 1978
This study was designed to identify a method for the measurement of human high density lipoprotein subfraction (HDL2 and HDL3) metabolism. Apolipoproteins A-I, A-II, and C, the major HDL apoproteins, were radioiodinated and incorporated individually into
J Shepherd, J R Patsch, C J Packard, A M Gotto, Jr, O D Taunton   +4 more
doaj  

A Study of Skeletal Stem Cell Dynamics and Its Potential Applications in the Design of a Titanium Implant for Senile Osteoporosis

Advanced Science, EarlyView.
Senescent mesenchymal stromal cells (MSCs) drive age‐related osteoporosis (A‐OP) via adipogenic bias. Resveratrol, selected from transcriptome‐identified core genes, is delivered locally using GelMA‐chitosan hydrogel‐functionalised titanium implants. In A‐OP microenvironments, the hydrogel enables the sustained release of resveratrol, which reverses ...
Wuzhe Fan, Tao Zheng, Mingsong Mao, Pengfei Gao, Yulu Yang, Rong Wang, Yao Yang, Yangpeng Zuo, Tiantian Yuan, Ruqing Bai, Weihu Yang, Xingchen Yan, Kaiyong Cai   +12 more
wiley   +1 more source

Mediterranean Diet Improves High-Density Lipoprotein Function in High-Cardiovascular-Risk Individuals: A Randomized Controlled Trial

Circulation, 2017
Á. Hernáez, O. Castañer, R. Elosúa, X. Pintó, R. Estruch, J. Salas‐Salvadó, D. Corella, F. Arós, L. Serra-Majem, M. Fiol, M. Ortega-Calvo, E. Ros, M. Martínez-González, R. de la Torre, M. Lopez-Sabater, M. Fitó   +15 more
semanticscholar   +1 more source

Interrelationship between rat serum very low density and high density lipoproteins

, 1972
Bernard Rubenstein, David Rubinstein
openalex   +1 more source

AI‐Driven De Novo Design of Ultra Long‐Acting GLP‐1 Receptor Agonists

Advanced Science, EarlyView.
De novo GLP‐1RAs can be computationally designed to exhibit extended half‐life and superior efficacy compared to Semaglutide. Abstract Peptide drugs have revolutionized modern therapeutics, offering novel treatment avenues for various diseases. Nevertheless, low design efficacy, time consumption, and high cost still hinder peptide drug design and ...
Ting Wei, Jiating Ma, Xiaochen Cui, Jiahui Lin, Zhuoqi Zheng, Liu Cheng, Taiying Cui, Xiaoqian Lin, Junjie Zhu, Xuyang Ran, Xiaokun Hong, Luke Johnston, Zhangsheng Yu, Haifeng Chen   +13 more
wiley   +1 more source

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

Nature Genetics, 2008
S. Kathiresan, S. Kathiresan, O. Melander, C. Guiducci, Aarti Surti, N. Burtt, M. Rieder, G. Cooper, C. Roos, B. Voight, B. Voight, A. Havulinna, B. Wahlstrand, T. Hedner, D. Corella, E. Tai, J. Ordovás, G. Berglund, E. Vartiainen, P. Jousilahti, B. Hedblad, M. Taskinen, C. Newton‐Cheh, C. Newton‐Cheh, V. Salomaa, L. Peltonen, L. Groop, L. Groop, D. Altshuler, M. Orho-Melander   +29 more
semanticscholar   +1 more source

L-shaped association of the non-high-density lipoprotein to high-density lipoprotein ratio with low bone mass disorders. [PDF]

Sci Rep
Chen X, Du W, Li H, Wang J, Wang Y, Zhao J.   +5 more
europepmc   +1 more source

Nature of the interaction of dextran sulfate with high and low density lipoproteins in the presence of Ca2+.

, 1979
Young C. Kim, T Nishida
openalex   +1 more source