Results 121 to 130 of about 20,125,779 (304)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Summaries of FY 1977, research in high energy physics [PDF]

, 1977
The U.S. Department of Energy, through the Office of Energy Research and the Division of High Energy and Nuclear Physics, provides approximately 90% of the total federal support for high energy physics research effort in the United States.

core   +1 more source

Probing large extra dimension at DUNE using beam tunes

Journal of High Energy Physics
The Deep Underground Neutrino Experiment (DUNE) is a leading experiment in neutrino physics which is presently under construction. DUNE aims to measure the yet unknown parameters in the three flavor oscillation case which includes discovery of leptonic ...
Kim Siyeon, Suhyeon Kim, Mehedi Masud, Juseong Park   +3 more
doaj   +1 more source

Radiation Hardness Study of Single-Photon Avalanche Diode for Space and High Energy Physics Applications. [PDF]

Sensors (Basel), 2022
Wu ML, Ripiccini E, Kizilkan E, Gramuglia F, Keshavarzian P, Fenoglio CA, Morimoto K, Charbon E.   +7 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Estimates of the neutron fluence for the SDC detector [PDF]

, 1992
The high energy and high luminosity of SSC cause radiation problems to detectors. Almost all the radiation in the SDC detector comes from the 20 TeV on 20 Tev pp collisions. The design luminosity corresponds to 10[sup 8] collisions per second.
Job, P.K., Handler, T. (Tennessee Univ., Knoxville, TN (United States)), Gabriel, T.A. (Oak Ridge National Lab., TN (United States)), Price, L.E. (Argonne National Lab., IL (United States). High Energy Physics Div.)   +3 more
core   +1 more source

Digital Twins in the Practice of High-Energy Physics Experiments: A Gas System for the Multipurpose Detector. [PDF]

Sensors (Basel), 2022
Chaber P, Domański PD, Dąbrowski D, Ławryńczuk M, Nebeluk R, Plamowski S, Zarzycki K.   +6 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source