Results 51 to 60 of about 264,049 (257)

Observation of the decay ψ(3686) → Σ − Σ ¯ + $$ {\Sigma}^{-}{\overline{\Sigma}}^{+} $$ and measurement of its angular distribution

open access: yesJournal of High Energy Physics, 2022
Using (448.1 ± 2.9) × 106 ψ(3686) events collected with the BESIII detector at the BEPCII collider, the decay ψ(3686) → Σ − Σ ¯ + $$ {\Sigma}^{-}{\overline{\Sigma}}^{+} $$ is observed for the first time with a branching fraction of (2.82 ± 0.04stat.
The BESIII collaboration   +576 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and construction of High Energy Photon Source (HEPS) scientific data storage system [PDF]

open access: yesEPJ Web of Conferences
The High Energy Photon Source (HEPS), one of the world’s brightest fourth-generation synchrotron radiation facilities, requires a scientific data storage system capable of managing exabyte-scale datasets, high-concurrency access, and long-term ...
Chengys Yaosong, Hu Qingbao, Yao Qiuling
doaj   +1 more source

Measurement of the cross section of e + e − → ηπ + π − at center-of-mass energies from 3.872 GeV to 4.700 GeV

open access: yesJournal of High Energy Physics, 2022
Using data samples with an integrated luminosity of 19 fb −1 at twenty-eight center-of-mass energies from 3.872 GeV to 4.700 GeV collected with the BESIII detector at the BEPCII electron-positron collider, the process e + e − → ηπ + π − and the ...
The BESIII collaboration   +574 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Design and implementation of experimental data access security policy for HEPS container computing platform [PDF]

open access: yesEPJ Web of Conferences
China’s High-Energy Photon Source (HEPS), the first national highenergy synchrotron radiation light source, is under design and construction. In the future, at the first stage of HEPS, it is predicted that 24PB raw experimental data will be produced per ...
Hu Qingbao   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

The design, experiment investigation, and experience of 324 MHz/3 MW klystron power source system for CSNS Linac

open access: yesAIP Advances
There are five sets of pulse type 324 MHz triode klystron power sources in the China Spallation Neutron Source (CSNS) Linac Radio Frequency (RF) system that provide high frequency power for the RFQ accelerator and four Drift Tube Linac (DTL) accelerators,
Zhencheng Mu   +11 more
doaj   +1 more source

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