Results 51 to 60 of about 2,054,795 (277)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Fast muon simulation in the JUNO experiment with neural networks [PDF]
EPJ Web of ConferencesThe Jiangmen Underground Neutrino Observatory (JUNO) experiment is set to begin data taking in 2024 with the aim of determining the neutrino mass ordering (NMO) to a significance of 3 σ after 6 years of data taking. Achieving this goal requires effective
Fang Wenxing, Li Weidong, Lin Tao
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
High Energy Physics and Quintessence [PDF]
, 2000 It is shown that any realistic model of quintessence should be based on Supergravity (SUGRA) since the value of the quintessence field on the attractor is approximately the Planck mass.
Brax, Philippe, Martin, Jerome
core +2 more sources
Publication patterns in HEP computing
, 2012 An overview of the evolution of computing-oriented publications in high energy physics following the start of operation of LHC. Quantitative analyses are illustrated, which document the production of scholarly papers on computing-related topics by high ...
Basaglia, T. +3 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
dN/dx reconstruction with deep learning for high-granularity TPCs
Journal of High Energy PhysicsParticle identification (PID) is essential for future particle physics experiments such as the Circular Electron-Positron Collider (CEPC) and the Future Circular Collider.
Guang Zhao +10 more
doaj +1 more source
HEPS scientific computing platform design for interactive data analysis scenarios [PDF]
EPJ Web of ConferencesThe High Energy Photon Source (HEPS), located at Beijing HuaiRou, is an advanced public platform for multidisciplinary innovation research and high-tech development, as well as understanding many scientific questions in the fields of physics, chemistry ...
Hu Qingbao +5 more
doaj +1 more source