Results 21 to 30 of about 1,236,846 (239)

Theoretical Research in Cosmology, High-Energy Physics and String Theory [PDF]

, 2013
The research was in the area of Theoretical Physics: Cosmology, High-Energy Physics and String ...
Ng, Y Jack, Dolan, Louise, Mersini-Houghton, Laura, Frampton, Paul   +3 more
openaire   +2 more sources

Decoupling in an expanding universe: boundary RG-flow affects initial conditions for inflation

, 2004
We study decoupling in FRW spacetimes, emphasizing a Lagrangian description throughout. To account for the vacuum choice ambiguity in cosmological settings, we introduce an arbitrary boundary action representing the initial conditions.
A. Strominger, A.A. Starobinsky, A.J. Hamilton, C. Grosse-Knetter, C.P. Burgess, C.P. Burgess, C.P. Burgess, C.P. Burgess, D. Deutsch, D.J.H. Chung, E. Witten, F. Larsen, F. Larsen, G. Barton, Gary Shiu, H. Collins, H. Collins, J. Martin, J. Martin, J.P. van der Schaar, Jan Pieter van der Schaar, K. Goldstein, K. Goldstein, K. Graham, Koenraad Schalm, M. Bastero-Gil, M.B. Einhorn, M.B. Einhorn, N. Kaloper, N.D. Birrell, O. Aharony, P. Candelas, R. Easther, R.G. Leigh, R.H. Brandenberger, R.L. Jaffe, S. Shankaranarayanan, T. Banks, T. Tanaka, U.H. Danielsson, V. Bozza, Y. Aghababaie   +41 more
core   +2 more sources

New Physics at High-Energy: An Effective-Theory Approach

, 2022
In this document I summarise the main research results carried out during my Ph.D. at University of Geneva, in the period 2018-2022, under the supervision of Prof. Francesco Riva. My published works represent the main content of this document. Along with them the initial chapter largely introduces their context, aims, methods and results.
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Consistent effective description of nucleonic resonances in an unitary relativistic field-theoretic way [PDF]

, 1998
High energy strong interaction physics is successfully described by the local renormalizable gauge theory called Quantum-Chromo-Dynamics (QCD) with quarks and gluons as ``elementary'' degrees of freedom, while intermediate energy strong interaction ...
Kleefeld, F.
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source