Results 101 to 110 of about 20,225 (295)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Multi-Level DC-DC Converter for High Gain Applications

, 2013
The output voltage from most renewable energy sources like photovoltaic arrays and fuel cells will be at low level. This must be stepped up considerably for practical utilization or grid connection.
Ganesan R, Girish, Prabhakar, M.
core  

A high gain modified SEPIC DC-to-DC boost converter for renewable energy application

, 2017
The proposed work present the modified high gain Single Ended Primary Inductance Converter (SEPIC) for renewable energy applications. The voltage gain of proposed converter is very highly related to conventional dc-to-dc converter and recently projected ...
Sanjeevikumar Padmanaban, Bhaskar, Mahajan Sagar, Ramachandaramurthy, Vigna K., Fedák, Viliam, Blaabjerg, Frede, Blaabjerg, Frede; id_orcid, Viliam Fedak, Pierluigi Siano, Maroti, Pandav Kiran, Mahajan Sagar Bhaskar, Pandav Kiran Maroti, Padmanaban, Sanjeevikumar, Siano, Pierluigi, Bhaskar , Mahajan Sagar, Frede Blaabjerg, Vigna K. Ramachandaramurthy   +15 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

An analytical design and analysis of a high gain switched inductor voltage multiplier cell power converter

Automatika
The proposed modified higher gain boost converter employs switched Inductor and multiplier cell-based voltage boosting techniques, as the paper represents. This converter is modelled to enhance the static gain and efficiency. As the designed topology has
K. Jayanthi, J. Gnanavadivel
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Wide-Input High-Step-Up DC–DC Converter with High Efficiency and High Voltage Gain

Energies
This study proposes a wide-input high-step-up DC–DC converter with high efficiency and high voltage conversion ratio. Two coupled inductors were adopted to achieve a parallel-charging and series-discharging energy transfer mechanism, and a voltage ...
Yu-En Wu, Wei-Shan Lin
doaj   +1 more source