Results 121 to 130 of about 194,412 (299)

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

Elevated hydrostatic pressure destabilizes VE-cadherin junctions in a time and shear stress dependent manner: An endothelium-on-chip study

APL Bioengineering
Despite the effects of shear stress on endothelial biology having been extensively researched, the effects of hydrostatic vascular pressure at extremely low shear stresses have been largely ignored. In the current study, we employ a microfluidic organ-on-
Pranav Vasanthi Bathrinarayanan, Thomas Abadie, Patricia Perez Esteban, D. Vigolo, M. J. H. Simmons, L. M. Grover   +5 more
doaj   +1 more source

Bioinspired Hierarchical Architecture with Water Transport Channels for Strong Adhesion at the Sweating Interface

Advanced Science, EarlyView.
To address adhesion failure in sweaty epidermal electronics, this study proposes a cross‐species, multi‐scale biomimetic interface. By modeling staged wet adhesion, it integrates self‐regulating liquid bridges with directional drainage. This design ensures stable, high‐performance flexible sensing in complex physiological environments, offering a ...
Jieliang Zhao, Yu Xiang, Heng Wang, Huiqing Xu, Zhong Liu, Lulu Liang, Fengwen Jiang, Xuemei Chen, Wenzhong Wang, Chenqing Liu, Guodong Liu, Shaoze Yan, Xu Hou   +12 more
wiley   +1 more source

High hydrostatic pressure stimulates microbial nitrate reduction in hadal trench sediments under oxic conditions

Nature Communications
Hadal trenches are extreme environments situated over 6000 m below sea surface, where enormous hydrostatic pressure affects the biochemical cycling of elements.
Na Yang, Yongxin Lv, Mukan Ji, Shiguo Wu, Yu Zhang   +4 more
doaj   +1 more source

The impact of high hydrostatic pressure maintenance after high-pressure torsion on phenomena during high hydrostatic pressure annealing

Materials Science and Engineering: A, 2022
Agnieszka Teresa Krawczynska, Michael Kerber, Przemyslaw Suchecki, Barbara Romelczyk-Baishya, Maciej Oskar Liedke, Maik Butterling, Eric Hirschmann, Andreas Wagner, Malgorzata Lewandowska, Daria Setman   +9 more
openaire   +3 more sources

All‐in‐One Underwater Quality Evaluation Metamaterial With Mechanical Robustness, Sound Attenuation, and Diffuse Reflection

Advanced Science, EarlyView.
In this work, a bioinspired all‐in‐one underwater quality evaluation metamaterial, combining sound attenuation, diffuse reflection, and mechanical robustness, is proposed based on jumping spider locomotion and human skeletal biomechanics. Meanwhile, a CNN‑driven quality evaluation framework is established for theoretically dimension‐reduced ...
Hongze Li, Zhenyu Li, Jinshui Yang, Jianhao Wu, Yidan Chen, Linzhi Wu, Hong Hu, Penglin Gao, Yegao Qu   +8 more
wiley   +1 more source

Miniaturized 3D Magnetic Force Sensor via Laser‐Assisted Folding and Magnetization for Enhanced Robotic Dexterity

Advanced Science, EarlyView.
To achieve 3D force sensing in confined spaces such as fingertips, we developed a laser‐assisted folding and magnetization method to fabricate miniature films with precise centripetal magnetization. The resulting compact sensor delivers high force resolution, rapid response, and long‐term stability, significantly enhancing the manipulation capabilities
Yujie Huang, Huangzhe Dai, Chengqian Zhang, Daofan Tang, Xinxin Zhang, Haonan Sun, Annan Ding, Xuebin Ni, Yizhi Zhang, Chengfeng Pan, Peng Zhao   +10 more
wiley   +1 more source

Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions

Advanced Science, EarlyView.
It is currently not well understood how cells regulate basic properties, e.g., volume and mechanics within dense multicellular environments like tumors. Here, we show that different cell types of cancer and also normal cells largely decrease their nuclear and cellular volumes in emerging cell clusters and that this is partly driven by cell cycle shifts.
Vaibhav Mahajan, Keshav Gajendra Babu, Markus Mukenhirn, Antje Garside, Vinita Ajit Kini, Trishla Adhikari, Timon Beck, Byung Ho Lee, Kyoohyun Kim, Carsten Werner, Raimund Schlüßler, Alf Honigmann, Sebastian Aland, Anna Verena Taubenberger   +13 more
wiley   +1 more source

Effect of moderate hydrostatic pressure on crystallization of palm kernel stearin-sunflower oil model systems

Current Research in Food Science
Lipid crystallization under moderate hydrostatic pressure treatments (200 MPa, 20 °C, 1–24 h) was studied in palm kernel stearin (PS 100%) and its blends with sunflower oil (PS 80, 90 % w/w).
Federico Basso, Francesco Ciuffarin, Miriam Chiodetti, Marcello Alinovi, Eleonora Carini, Luisa Barba, Lara Manzocco, Maria Cristina Nicoli, Sonia Calligaris   +8 more
doaj   +1 more source

Ultrafast Interfacial Engineering for Quantifiable Control of Asymmetric Configurations in Nanostructured Janus Membranes

Advanced Science, EarlyView.
Founded on a rapidly formed nanostructured tannic acid/polyethyleneimine (TA/PEI) platform, an ultrafast (∼5 min), universal interfacial engineering strategy utilizing stearoyl chloride (SC) and Phytic acid (PA) enables precise fabrication of Janus membranes across diverse substrates.
Wenqing Zhang, Jinhui Xu, Bo Li, Yao Li, Yue Zhang, Zhishu Tang, Huaxu Zhu, Jingwei Hou   +7 more
wiley   +1 more source