Results 241 to 250 of about 64,396 (303)

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Skin burns after high-intensity focused ultrasound ablation: a retrospective control study. [PDF]

Sci Rep
Wu S, Liu J, Tang Y, Yang L, Han Y.
europepmc   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Protocol for high‐intensity focused ultrasound (HIFU) treatment of cutaneous neurofibromas

JEADV Clinical Practice
Mimmi Tang, Katrine Elisabeth Karmisholt, Martin Gillstedt, Jaishri O. Blakeley, Joshua Roberts, Jørgen Serup, Torsten Bove, Sirkku Peltonen   +7 more
doaj   +1 more source

Traumatic cataract following high-intensity focused ultrasound eyelid procedure. [PDF]

Arq Bras Oftalmol
Moreira Neto CA, Rêgo Neto JPD, Meister T.   +2 more
europepmc   +1 more source

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

Salvage Radiation Therapy for Localised Prostate Cancer Recurrence Following High-Intensity Focused Ultrasound (HIFU) Failure. [PDF]

J Med Imaging Radiat Oncol
Katano A, Minamitani M, Sawayanagi S, Yamashita H.   +3 more
europepmc   +1 more source

MRI-Based Classification Systems Combined with Serum CA125 for Predicting Symptom Recurrence After Ultrasound-Guided High-Intensity Focused Ultrasound Ablation Surgery for Adenomyosis: A Retrospective Cohort Study. [PDF]

Int J Womens Health
Tang Y, Tian HD, Chen XM, Wang H, Shen LM, Ni SQ, Su B, Jiang ZJ, Zhu LJ, Luo YX, Shi Q.   +10 more
europepmc   +1 more source

EC₅₀ and EC₉₅ of Epidural Ropivacaine for Intraoperative Analgesia During High-Intensity Focused Ultrasound for Adenomyosis: A Prospective Double-Blind Up-and-Down Concentration-Finding Study. [PDF]

Drug Des Devel Ther
Yang S, Zhang Y, Yang F, Luo L.
europepmc   +1 more source