Results 191 to 200 of about 414,061 (317)

2D-dwell-time analysis with simulations of ion-channel gating using high-performance computing. [PDF]

Biophys J, 2023
Oikonomou E, Gruber T, Chandra AR, Höller S, Alzheimer C, Wellein G, Huth T.   +6 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Balancing energy and performance: efficient allocation of solver jobs on high-performance computing systems

Many combinatorial optimization methods and related optimization software, particularly those for mixed-integer programming, exhibit limited scalability when utilizing parallel computing resources, whether across multiple cores or multiple nodes ...
Neumann, Philipp, Leinen, Willi Günter, Fink, Andreas   +2 more
core   +1 more source

Benchmarking Radiation Transport Monte Carlo Simulations with MCNP and Geant4 Using High Performance Computing. [PDF]

Health Phys
Moats K, Desrosiers M, Linton G, Wood R.
europepmc   +1 more source

Hyperparameter Tuning with High Performance Computing Machine Learning for Imbalanced Alzheimer's Disease Data. [PDF]

Appl Sci (Basel), 2022
Zhang F, Petersen M, Johnson L, Hall J, O'Bryant SE.   +4 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Frag'n'Flow: automated workflow for large-scale quantitative proteomics in high performance computing environments. [PDF]

BMC Bioinformatics
Szepesi-Nagy I, Borosta R, Szabo Z, Tusnady GE, Pongor LS, Rona G.   +5 more
europepmc   +1 more source

High Performance Business Computing [PDF]

Business & Information Systems Engineering, 2019
Guido Schryen, Natalia Kliewer, Andreas Fink   +2 more
openaire   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

MorphoCloud: Democratizing Access to High-Performance Computing for Morphological Data Analysis. [PDF]

F1000Res
Maga AM, Fillion-Robin JC.
europepmc   +1 more source