Results 191 to 200 of about 22,385,248 (304)

Democratising high performance computing for bioinformatics through serverless cloud computing: A case study on CRISPR-Cas9 guide RNA design with Crackling Cloud. [PDF]

PLoS Comput Biol
Bradford J, Joy D, Winsen M, Meurant N, Wilkins M, Wilson LOW, Bauer DC, Perrin D.   +7 more
europepmc   +1 more source

Perspective of drug design with high-performance computing. [PDF]

Natl Sci Rev, 2021
Li Z, Li H, Yu K, Luo HB.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Scale-up Unlearnable Examples Learning with High-Performance Computing. [PDF]

IS&T Int Symp Electron Imaging
Zhu Y, Lyngaas I, Gopalakrishnan Meena M, Koran MEI, Malin B, Moyer D, Bao S, Kapadia A, Wang X, Landman B, Huo Y.   +10 more
europepmc   +1 more source

High Performance Business Computing [PDF]

Business & Information Systems Engineering, 2019
Guido Schryen, Natalia Kliewer, Andreas Fink   +2 more
openaire   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Integration of nested cross-validation, automated hyperparameter optimization, high-performance computing to reduce and quantify the variance of test performance estimation of deep learning models. [PDF]

Comput Methods Programs Biomed
Calle P, Bates A, Reynolds JC, Liu Y, Cui H, Ly S, Wang C, Zhang Q, de Armendi AJ, Shettar SS, Fu KM, Tang Q, Pan C.   +12 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

ComPRePS 2.0: Enabling Massive-Scale Distributed Computing on High-Performance Computing Cluster for Histopathological Data Processing. [PDF]

Proc SPIE Int Soc Opt Eng
Kumar SKC, Paul AS, Abdelazim H, Dunklin W, Manthey D, Moskalenko O, Mimar S, Deumens E, Sarder P.   +8 more
europepmc   +1 more source

High Performance Computing PP-Distance Algorithms to Generate X-ray Spectra from 3D Models. [PDF]

Int J Mol Sci, 2022
González C, Balocco S, Bosch J, de Haro JM, Paolini M, Filgueras A, Álvarez C, Pons R.   +7 more
europepmc   +1 more source