Results 171 to 180 of about 414,061 (317)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Don Lindberg, High performance computing and communications, and telemedicine. [PDF]

Inf Serv Use, 2022
Ackerman MJ, Howe SE, Masys DR.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Implementations of the Integrated Linux, Windows and Macintosh Cluster for achieving the Personal High Performance Computing

, 2006
The motivation and objective for this paper is to demonstrate (1) the integrated Linux (30 distributions, including Red Hat and SUSE), Windows (Cluster 2003 and Server 2003) and Macintosh (Tiger 10.4) cluster for running Web Services and jobs; and (2 ...
Chang, Victor
core  

Developing Distributed High-performance Computing Capabilities of an Open Science Platform for Robust Epidemic Analysis. [PDF]

IEEE Int Symp Parallel Distrib Process Workshops Phd Forum, 2023
Collier N, Wozniak JM, Stevens A, Babuji Y, Binois M, Fadikar A, Würth A, Chard K, Ozik J.   +8 more
europepmc   +1 more source

High-performance computational biology [PDF]

Parallel Computing, 2008
David A. Bader, Srinivas Aluru
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

High-Performance Pervasive Computing

, 2012
In the area of next-generation mobile and pervasive grids, this chapter addresses the following issues: 1) mechanisms to express location & context-awareness, 2) uniform mechanisms to express parallel and distributed high-performance and fault-tolerant ...
BERTOLLI, CARLO, MENCAGLI, GABRIELE, VANNESCHI, MARCO   +2 more
core  

Profiling the BLAST bioinformatics application for load balancing on high-performance computing clusters. [PDF]

BMC Bioinformatics, 2022
Cheng T, Chin PJ, Cha K, Petrick N, Mikailov M.   +4 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source