Results 161 to 170 of about 22,385,248 (304)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Performance-responsive middleware for grid computing [PDF]

The development of supportive middleware to manage resources and distributed workload across multiple administrative boundaries is of central importance to Grid computing.
Nudd, G. R., Dyson, J. R. D., Zhao, Lei, Spooner, Daniel P., Jarvis, Stephen A.   +4 more
core  

Complex Linear Response Functions for a Multiconfigurational Self-Consistent Field Wave Function in a High Performance Computing Environment. [PDF]

J Chem Theory Comput, 2023
Scott M, Delcey MG.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Retracted: Innovative Research on Urban Community Governance Decision-Making Relying on Distributed High-Performance Computing Blockchain Key Algorithms. [PDF]

Comput Intell Neurosci, 2023
Intelligence And Neuroscience C.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Neuro-Cardiac Symbiotic Engine: A Multimodal Fusion Architecture for Cognitive State Decoding via High-Performance Computing. [PDF]

Life (Basel)
Bastidas-Benalcazar N, Calero-Apunte JA, Almeida-Galarraga D, Navas-Boada P, Alvarado-Cando O, Tirado-Espín A, Villalba-Meneses F, Carvajal Mora H, Orozco Garzón N.   +8 more
europepmc   +1 more source

2D-dwell-time analysis with simulations of ion-channel gating using high-performance computing. [PDF]

Biophys J, 2023
Oikonomou E, Gruber T, Chandra AR, Höller S, Alzheimer C, Wellein G, Huth T.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Retraction Note: COVID-19 Detection using adopted convolutional neural networks and high-performance computing. [PDF]

Multimed Tools Appl
Singh AK, Kumar A, Kumar V, Prakash S.
europepmc   +1 more source