Results 141 to 150 of about 197,600 (258)

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

A comparative study between Near-Infrared (NIR) spectrometer and High-Performance Liquid Chromatography (HPLC) on the sensitivity and specificity. [PDF]

PLoS One
Maffioli EM, Anyakora C.
europepmc   +1 more source

Utilizing High-Performance Liquid Chromatography (HPLC) in Clinical Diagnostics

High-Performance Liquid Chromatography (HPLC) stands as a robust analytical technique with extensive applications in clinical diagnostics. Its versatility enables the precise separation, identification, and quantification of complex mixtures in biological samples.
Fatemeh Keyfi, Amin Alaei, Hadiseh Mirahmadi Daryasari, Ali Hakimi, Pouya Gharavi   +4 more
openaire   +1 more source

Atroposelective Construction of Axially Chiral Tetraarylethenes Via NHC‐Catalyzed Desymmetrization

Advanced Science, EarlyView.
We report the first NHC‐catalyzed atroposelective synthesis of axially chiral TAEs via oxidative desymmetrization of prochiral TAE dialdehydes. This catalytic strategy operates under mild conditions and accommodates a broad range of phenolic and nitrogen nucleophiles, delivering diverse axially chiral TAEs in good yields and up to 99% ee.
Yang‐Ze Zheng, Ting‐Rui Luan, Ming‐Hao Song, Zhaofeng Sun, Chuan‐Jun Lu, Long‐Long Xi, Ren‐Rong Liu   +6 more
wiley   +1 more source

Removal of Emerging Contaminants (Endocrine Disruptors) Using a Photocatalyst and Detection by High-Performance Liquid Chromatography (HPLC). [PDF]

Int J Environ Res Public Health
Santos MS, Mourão AO, Santos TSX, Rodriguez MDVR, Faria MCDS, Franco ES, Aguilar NA, Rodrigues JL.   +7 more
europepmc   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

4-Methyl-3-penten-2-one - Determination of 4-methyl-3-penten-2-one (mesityl oxide) in the workplace air using high-performance liquid chromatography (HPLC-DAD): Air Monitoring Method - Translation of the German version from 2025. [PDF]

MAK Collect Occup Health Saf
Nitschke L, Frenzen A, Breuer D, Hebisch R, Lewin-Kretzschmar U, Hartwig A, MAK Commission .   +6 more
europepmc   +1 more source

Cobalt Single‐Atom Catalysts for Ultrafast Sulfamethoxazole Degradation: Unveiling the Chloride‐Ion‐Enhanced Formation of Co(IV)=O

Advanced Science, EarlyView.
An atomically dispersed Co–N4 single‐atom catalyst rapidly activates peroxymonosulfate to remove the antibiotic sulfamethoxazole from water. Common ions have little impact, but chloride dramatically speeds degradation by promoting a high‐valent Co(IV) = O oxidant via in situ HOCl–catalyst electron transfer.
Anting Ding, Jing Lu, Yafei Fan, Chenyu Zeng, Yuhang Lin, Yufei Shi, Zulin Zhang   +6 more
wiley   +1 more source

High-Performance Liquid Chromatography (HPLC) Method Validation for Identifying and Quantifying Rebamipide in Ethosomes. [PDF]

Cureus
Kako D, Ghareeb MM, Al-Lami MS.
europepmc   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source