Results 131 to 140 of about 20,817,051 (316)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Characterization of non-equilibrium condensate flow loss of H2O/CO2 mixed working fluids in cascade

Reli fadian
Supercritical water coal gasification for hydrogen production is a clean and efficient power generation technology. Based on entropy generation theory, numerical investigation on the non-equilibrium condensation flow of an H2O/CO2 mixed working fluid in ...
HAN Zhonghe, WU Xuwei, HAN Xu, YAO Bochuan, SHI Haibo   +4 more
doaj   +1 more source

High voltage power amplifier for high precision mechatronic systems

, 2018
Mechatronic systems within industrial applications, e.g. semiconductor manufacturing equipment, require power amplifiers providing high power with high precision.
van Duivenbode, J., Duarte, J.L., Duarte, JL Jorge, Duarte, J.L.; id_orcid, Settels, SJ Sjef, Wijnands, CGE Korneel, Duivenbode, J Jeroen van, Settels, S.J., Wijnands, C.G.E.   +8 more
core  

What is BPA?

, 1996
This PR pamphlet explains what BPA (Bonneville Power Administration) is (a Federal agency with a Northwest focus). It plays a role in balancing river uses; power revenues pay BPA costs; renewable resource aspects are discussed; fish and wildlife ...
United States. Bonneville Power Administration.
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Probabilistic Risk Assessment and Robust MOV–RC Design for High-Frequency Overvoltage Under Random Multiple Reignition in 35-kV Shunt Reactors

IEEE Access
Circuit-breaker reignition during the switching of 35 kV shunt reactors may excite high-frequency oscillations between the reactor equivalent inductance and the ground capacitance of cables, busbars, and connected equipment, resulting in shortduration ...
Yanan Zhang, Ao Guo, Xiao Zhang, Xiaoqing Zhang, Xiangfeng Wang, Xiwen Chen   +5 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source